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Record W3161658709 · doi:10.1038/s41592-021-01169-5

Diversity in immunogenomics: the value and the challenge

2021· article· en· W3161658709 on OpenAlexafffund
Kerui Peng, Yana Safonova, Mikhail Shugay, Alice B. Popejoy, Oscar L. Rodriguez, Felix Breden, Petter Brodin, Amanda M. Burkhardt, Carlos D. Bustamante, Van‐Mai Cao‐Lormeau, Martin Corcoran, Darragh Duffy, Macarena Fuentes‐Guajardo, Ricardo Fujita, Victor Greiff, Vanessa D. Jönsson, Xiao Liu, Lluís Quintana‐Murci, Maura Rossetti, Jianming Xie, Gur Yaari, Wei Zhang, Malak S. Abedalthagafi, Khalid O. Adekoya, Rahaman A. Ahmed, Wei‐Chiao Chang, Clive M. Gray, Yusuke Nakamura, William Lees, Purvesh Khatri, Houda Alachkar, Cathrine Scheepers, Corey T. Watson, Gunilla B. Karlsson Hedestam, Serghei Mangul

Bibliographic record

VenueNature Methods · 2021
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmune Cell Function and Interaction
Canadian institutionsSimon Fraser University
FundersNational Cancer InstituteNational Institute on AgingUniversity of California, San DiegoFogarty International CenterUniversity of California, Los AngelesTsinghua Shenzhen International Graduate SchoolSchool of Pharmacy, University of Southern CaliforniaDirectorate for Biological SciencesNational Institutes of HealthBill and Melinda Gates FoundationKarolinska InstitutetPirogov Russian National Research Medical UniversityNational Human Genome Research InstituteUniversitetet i OsloCentre National de la Recherche ScientifiqueSimon Fraser UniversityUniversidad de TarapacáDr. Ralph and Marian Falk Medical Research TrustTsinghua UniversityMinistry of Science and Higher Education of the Russian FederationBeckman Research Institute, City of HopeUniversity of Southern CaliforniaNational Institute of Allergy and Infectious DiseasesRussian Academy of SciencesAgence Nationale de la RechercheNorges ForskningsrådJames S. McDonnell FoundationArizona Biomedical Research CommissionDavid Geffen School of Medicine, University of California, Los AngelesNational Science FoundationBar-Ilan UniversityScience for Life LaboratoryVetenskapsrådetMayo ClinicUniversity of LouisvilleU.S. Department of Defense
KeywordsDiversity (politics)BiologyEvolutionary biologyHuman genetic variationVariation (astronomy)Value (mathematics)Adaptive valueInclusion (mineral)Immune systemComputational biologyImmunologyGeneticsPsychologyHuman genomeComputer scienceSociologyGeneSocial psychologyGenomeAnthropology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.865
Threshold uncertainty score0.500

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.313
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations79
Published2021
Admission routes2
Has abstractno

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