The effect of compressive loading rate on annulus fibrosus strength following endplate fracture
Bibliographic record
Abstract
Intervertebral disc degeneration poses a considerable healthcare challenge, although the process is not well understood. Endplate fracture marks severe biomechanical compromise in a segment and may be correlated with degeneration of the disc. The purpose of this experiment was to investigate the relationship between endplate fracture velocity and damage to the annulus fibrosus. Following overnight-thawing, 27 frozen porcine cervical spines were dissected into motion segments (vertebra-disc-vertebra) and compressed until fracture at one of three loading rates (fast=15 mm/s, medium=1.5 mm/s, and slow=0.15 mm/s), or remained unfractured (control). Two annular samples were extracted and mechanically tested from each segment: 1) Bilayer samples underwent uniaxial tension to a stretch-ratio of 1.5; 2) Multilayer samples were delaminated with a 180° peel test configuration. All three rates of compression resulted in specimen fracture observed in the endplate and/or vertebra with varying degree of severity. Significant differences were detected in compressive strength and stiffness of motion segments when loaded at different rates of compression; interestingly these differences were not observed in the mechanical properties of the annulus fibrosus suggesting that at slow rates of loading, fracture of the endplate precedes destruction of the annulus fibrosus. In corroboration of these findings, gross and histological analysis reported no signs of annular disruption, strengthening assertions that annular damage did not occur.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".