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Record W3203631914 · doi:10.1080/21678421.2021.1980890

Genetic testing for amyotrophic lateral sclerosis in Canada – an assessment of current practices

2021· article· en· W3203631914 on OpenAlexaffabout
Kristiana Salmon, Nancy Anoja, Ari Breiner, Marvin Chum, Annie Dionne, Nicolas Dupré, Amanda Fiander, Daniel Fok, Amer A. Ghavanini, Sylvie Gosselin, Aaron Izenberg, Wendy Johnston, Sanjay Kalra, Geneviève Matte, Michel Melanson, Colleen O’Connell, Benjamin Ritsma, Kerri Schellenberg, Christen Shoesmith, Sandra Tremblay, Heather Williams, Angela Genge

Bibliographic record

VenueAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration · 2021
Typearticle
Languageen
FieldMedicine
TopicAmyotrophic Lateral Sclerosis Research
Canadian institutionsLondon Health Sciences CentreUniversity of SaskatchewanQueen's UniversityStan Cassidy FoundationUniversity of AlbertaSunnybrook Health Science CentreUniversity of British ColumbiaCentre Hospitalier Universitaire de SherbrookeUniversity of British Columbia, Okanagan CampusSt. Joseph’s Healthcare HamiltonTrillium Health CentreCentre Hospitalier de l’Université de MontréalUniversité LavalMcMaster UniversityCentre intégré de santé et de services sociaux de Chaudière-AppalachesHealth Sciences CentreOttawa HospitalKingston Health Sciences CentreMcGill UniversityMontreal Neurological Institute and Hospital
FundersBiogen
KeywordsGenetic testingGenetic counselingMedicineAmyotrophic lateral sclerosisFamily medicineHealth careDiseasePathology

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.998
Threshold uncertainty score0.505

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.007
Science and technology studies0.0050.002
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.129
GPT teacher head0.356
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designObservational
DomainMethods
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations20
Published2021
Admission routes2
Has abstractyes

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