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Record W3206255287 · doi:10.1016/s1474-4422(21)00301-x

Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

2021· article· en· W3206255287 on OpenAlexafffund
Antonio Uccelli, Alice Laroni, Rehiana Ali, Mario Alberto Battaglia, Morten Blinkenberg, Lou Brundin, Michel Clanet, Óscar Fernández, James Marriott, Paolo A. Muraro, Seyed Massood Nabavi, Roberto S Oliveri, Ernst W. Radue, Cristina Ramo‐Tello, Irene Schiavetti, Johann Sellner, Per Soelberg Sørensen, Maria Pia Sormani, Jens Wuerfel, Mark S. Freedman, Naser Aghdami, Eduardo Agüera, David Allan, Leila Arab, I. Berry, Bruno Bonetti, Chiara Capelli, Lucio Castellan, Maria Cellerino, Maria Teresa Cencioni, Gıancarlo Comı, David W. Courtman, Francesco Dazzi, Anne Fischer‐Nielsen, Victoria Fernández, Roberto Furlan, Mario Gimona, Francesca Gualandi, Qingdong Guan, Ellen Iacobaeus, Matilde Inglese, Martino Introna, Guillermo Izquierdo, Shahedeh Karimi, Katarina Le Blanc, Sandra Loaiza, Shahrukh Mallik, Stephen B. Marley, Ruth Ann Marrie, James Marriot, Gianvito Martino, David Miller, Richard Nicholas, Giovanni Orengo, Renuka Palanicawande, Matteo Pardini, Carolina Rush, Luc Sensebé, Dirk Strunk, David Szwajcer, Claire Thalamas

Bibliographic record

VenueThe Lancet Neurology · 2021
Typearticle
Languageen
FieldMedicine
TopicMesenchymal stem cell research
Canadian institutionsUniversity of OttawaOttawa HospitalUniversity of Manitoba
FundersMultiple Sclerosis International FederationInstituto de Salud Carlos IIIParacelsus Medizinische PrivatuniversitätRoyan InstituteMultiple Sclerosis Society of CanadaFondazione Italiana Sclerosi MultiplaFrench Muscular Dystrophy AssociationMultiple Sclerosis SocietyResearch ManitobaEuropean Committee for Treatment and Research in Multiple SclerosisUK Stem Cell FoundationAssociazione Italiana Sclerosi MultiplaScleroseforeningenBloddonorerne i DanmarkCompagnia di San PaoloToyota Foundation
KeywordsMedicineTolerabilityClinical endpointMultiple sclerosisPlaceboExpanded Disability Status ScaleAdverse effectMesenchymal stem cellInternal medicineClinical trialOncologySurgeryPathologyImmunology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.020
Threshold uncertainty score0.711

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.218
GPT teacher head0.375
Teacher spread0.157 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations109
Published2021
Admission routes2
Has abstractno

Explore more

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