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Record W3208590696 · doi:10.1038/s41587-021-01058-4

Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement

2021· article· en· W3208590696 on OpenAlexafffund
Kumar Gaurav, Sanu Arora, Paula Silva, Javier Sánchez‐Martín, Richard Horsnell, Liangliang Gao, Gurcharn S. Brar, Victoria Widrig, W. J. Raupp, Narinder Singh, Shuangye Wu, Sandip M. Kale, Catherine Chinoy, P. Nicholson, Jesús Quiroz-Chávez, James Simmonds, Şadiye Hayta, Mark A. Smedley, Wendy Harwood, Suzannah Pearce, David Gilbert, Ngonidzashe Kangara, Catherine Gardener, Macarena Forner-Martínez, Jiaqian Liu, Guotai Yu, Scott A. Boden, Attilio Pascucci, Sreya Ghosh, Amber N. Hafeez, Tom O’Hara, Joshua Waites, Jitender Cheema, Burkhard Steuernagel, Mehran Patpour, Annemarie Fejer Justesen, Shuyu Liu, Jackie C. Rudd, Raz Avni, Amir Sharon, Barbara Steiner, Rizky Pasthika Kirana, Hermann Buerstmayr, Ali Ashraf Mehrabi, Firuza Nasyrova, Noam Chayut, Oadi Matny, Brian J. Steffenson, Nitika Sandhu, Parveen Chhuneja, Evans Lagudah, Ahmed F. Elkot, Simon Tyrrell, Xingdong Bian, Robert Davey, Martin Simonsen, Leif Schauser, Vijay Tiwari, H. R. Kutcher, Pierre Hucl, Aili Li, Dengcai Liu, Long Mao, Steven S. Xu, Gina Brown‐Guedira, Justin D. Faris, Jan Dvořák, Ming‐Cheng Luo, Ksenia V. Krasileva, Thomas Lux, Susanne Artmeier, Klaus Mayer, Cristóbal Uauy, Martin Mascher, Alison R. Bentley, Beat Keller, Jesse Poland, Brande B. H. Wulff

Bibliographic record

VenueNature Biotechnology · 2021
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicWheat and Barley Genetics and Pathology
Canadian institutionsUniversity of SaskatchewanUniversity of British Columbia
FundersDepartment of Plant Sciences, University of California, DavisAgricultural Research ServiceNational Institute of Food and AgricultureDirectorate for Biological SciencesSaskatchewan Wheat Development CommissionDeutsches Zentrum für integrative Biodiversitätsforschung Halle-Jena-LeipzigUniversität ZürichPunjab Agricultural UniversityKementerian Riset, Teknologi dan Pendidikan TinggiNanjing Agricultural UniversitySichuan Agricultural UniversityTel Aviv UniversityIlam UniversityUniversity of British ColumbiaInstituto Nacional de Investigación AgropecuariaAarhus UniversitetJohn Innes FoundationOeAD-GmbHChinese Academy of Agricultural SciencesInnovationsfondenU.S. Department of AgricultureSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungKing Saud UniversityLeibniz-GemeinschaftResearch Councils UKUniversity of California, DavisACT GovernmentNational Natural Science Foundation of ChinaNational Science FoundationUK Research and InnovationUniversity of MinnesotaKing Abdullah University of Science and TechnologyDepartment of Biotechnology, Ministry of Science and Technology, IndiaInternational Center for Agricultural Research in the Dry AreasEuropean CommissionUniversità di BolognaKansas Wheat CommissionBiotechnology and Biological Sciences Research CouncilJewish National FundFulbright AssociationMinistry of Agriculture - SaskatchewanASEAN-European Academic University NetworkUniversitas Gadjah MadaInstituto Nacional de Investigación y Tecnología Agraria y AlimentariaÖsterreichische Agentur für Internationale Mobilität und Kooperation in Bildung, Wissenschaft und ForschungConsejo Nacional de Ciencia y TecnologíaUniversität für Bodenkultur WienRoyal Society
KeywordsAegilops tauschiiBiologyAegilopsPopulationGeneticsBiotechnologyGeneGenomeMedicine

Abstract

fetched live from OpenAlex

Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.233
Teacher spread0.224 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations287
Published2021
Admission routes2
Has abstractyes

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