SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance
Bibliographic record
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron strain (as known as B.1.1.529) was identified in Botswana and South Africa in early November 2021 and was later defined as a new variant of concern (VOC) by the World Health Organization on November 26, 2021. 1 , 2 To date, the confirmed cases of Omicron have been reported in more than 38 countries, and the number of cases appears to be rapidly increasing. SARS-CoV-2 Omicron could give rise to the fourth wave of the COVID-19 epidemic spreading around the world, following the D614G, Beta/Gamma, and Delta VOCs. Here, we showed Omicron variant causes serious immune escape from the convalescent sera from COVID-19 patients, still needs angiotensin-converting enzyme 2 (ACE2) as its receptor and exhibits a significantly increased infectivity. These substantial lines of evidence should attract broad attention to monitor its epidemic and accelerate the development of Omicron-targeted vaccines and therapeutic antibodies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.016 | 0.007 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".