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Record W4200539142 · doi:10.1371/journal.ppat.1010124

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

2021· review· en· W4200539142 on OpenAlexfundno aff
Laura E. de Vries, Matteo Lunghi, Aarti Krishnan, Taco W. A. Kooij, Dominique Soldati‐Favre

Bibliographic record

VenuePLoS Pathogens · 2021
Typereview
Languageen
FieldNeuroscience
TopicNeurological diseases and metabolism
Canadian institutionsnot available
FundersInstitute of GeneticsInstitute of Genetics and Genomics of GenevaEuropean Research CouncilRadboud Universitair Medisch CentrumNederlandse Organisatie voor Wetenschappelijk OnderzoekRadboud UniversiteitNetherlands Organization for International Cooperation in Higher EducationEuropean Commission
KeywordsBiologyApicomplexaApicoplastAntiparasitic agentAntiparasiticDrug discoveryPlasmodium (life cycle)Plasmodium falciparumComputational biologyBiochemistryMalariaParasite hostingPharmacology

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.982
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.081
GPT teacher head0.309
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2021
Admission routes1
Has abstractyes

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