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Record W4206349574 · doi:10.7554/elife.68174.sa2

Author response: Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy

2021· peer-review· en· W4206349574 on OpenAlexaff
Alexander Pasternak, Jelmer Vroom, Neeltje A. Kootstra, Ferdinand W.N.M. Wit, Marijn de Bruin, Davide De Francesco, Margreet Bakker, Caroline Sabin, Alan Winston, Jan M. Prins, Peter Reiss, Ben Berkhout, J. Schouten, KW Kooij, RA van Zoest, B C Elsenga, F R Janssen, M. Heidenrijk, W Zikkenheiner, Marc van der Valk, Thijs Booiman, A M Harskamp-Holwerda, Irma Maurer, MM Mangas Ruiz, AF Girigorie, Julien Villaudy, Esmay Frankin, AO Pasternak, T van der Kuyl, Peter Portegies, BA Schmand, Gert J. Geurtsen, JA ter Stege, M. Klein Twennaar, CBLM Majoie, MWA Caan, Tanja Su, Kees Weijer, P H L T Bisschop, Andries Kalsbeek, M Wezel, I. Visser, HG Ruhé, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Miriam Capri, Fabio Dall’Olio, Mariella Chiricolo, Stefano Salvioli, Jan H.J. Hoeijmakers, Joris Pothof, Maria Prins, M Martens, Solange Moll, J Berkel, M Totté, Sergey Y. Kovalev, Magnus Gisslén, Diana Fuchs, Henrik Zetterberg, Jonathan Underwood, L McDonald, Matthew A. Stott, Ken Legg, Andrew Lovell, Otto Erlwein, Nicki Doyle, Cherry Kingsley, DJ Sharp, Robert Leech, J. F. Cole, S Zaheri, M M J Hillebregt, Y M C Ruijs, D P Benschop, Dylan Burger, M de Graaff-Teulen, Giovanni Guaraldi, Alexander Bürkle, Thilo Sindlinger, María Moreno‐Villanueva, Amy Keller, Claude Libert, Sylviane Dewaele

Bibliographic record

Venuenot available
Typepeer-review
Languageen
FieldImmunology and Microbiology
TopicHIV Research and Treatment
Canadian institutionsInstitute of Infection and Immunity
Fundersnot available
KeywordsReverse transcriptaseReverse-transcriptase inhibitorNucleoside Reverse Transcriptase InhibitorProtease inhibitor (pharmacology)NucleosideRegimenRNAViral loadVirologyDNAAntiretroviral therapyHuman immunodeficiency virus (HIV)MedicineBiologyInternal medicineGeneGenetics

Abstract

fetched live from OpenAlex

In two independent cohorts, NNRTI-based cART regimens are associated with significantly lower cell-associated HIV RNA levels than PI-based regimens, suggesting more potent suppression of residual virus replication by NNRTI-based regimens.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.023
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.049
Threshold uncertainty score0.165

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.023
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0490.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.299
Teacher spread0.259 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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