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Record W4226424068 · doi:10.1186/s13063-022-06219-7

A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)

2022· article· en· W4226424068 on OpenAlexfundno aff
Pierre Malchair, Aurema Otero, Jordi Giol, Xavier Solanich, Thiago Carnaval, Alonso Fernández-Nistal, Ana Sánchez-Gabriel, Carmen Montoto, Ramón Lleonart, Sebastián Videla, Arnau Antolí, M Benjumeda, Tania Bernal, Laura Calatayud, Xavier Corbella, Anna Ferrer, Vanesa García‐Barberán, Mercè Gasa, Carlota Gudiol, Pilar Hereu, Javier Jacob, Hector Ignacio Jofré, Ferrán Llopis, Leire Matellán, Natàlia Pallarés, Raül Rigo‐Bonnin, Gemma Rocamora, Freddy Rodríguez, Alexander Rombauts, José Carlos Ruibal, Joan Sabater‐Riera, Carmen Serrano, Ana Suárez-Lledó, Cristian Tebé, Jesús Villoria, Alvaro Zarauza

Bibliographic record

VenueTrials · 2022
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsnot available
FundersUniversitat de BarcelonaCentres de Recerca de CatalunyaGeneralitat de CatalunyaCanadian Institute for Theoretical Astrophysics
KeywordsMedicineIcatibantRandomized controlled trialRandomizationCytokine stormClinical trialInternal medicineOff-label usePneumoniaCoronavirus disease 2019 (COVID-19)Intensive care medicineInfectious disease (medical specialty)BradykininDisease

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.022
metaresearch head score (Gemma)0.402
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.380
Threshold uncertainty score0.942

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0220.402
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0030.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.003
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.402
GPT teacher head0.573
Teacher spread0.172 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2022
Admission routes1
Has abstractyes

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