A112 EARLY USE OF THERAPEUTIC DRUG MONITORING TO INDIVIDUALIZE INFLIXIMAB THERAPY IN PAEDIATRIC IBD: A MULTICENTRE PROSPECTIVE COHORT STUDY
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Bibliographic record
Abstract
Utilization of therapeutic drug monitoring (TDM) to individualize biologic therapy is a logical strategy, given the variable drug clearance and multiple factors influencing pharmacokinetics. Indeed, previously documented wide variability of infliximab levels have been observed early post induction in pediatric patients. However, a randomized controlled trial in adults did not demonstrate improved outcomes with TDM implemented following induction phase of infliximab treatment. The aim of the study was to determine infliximab trough levels during induction therapy in children with IBD, with the goal to pre-emptively personalize maintenance dosing. Beginning in May 2016, children with IBD at participating sites in the Canadian Children IBD Network, when prescribed 3-dose infliximab induction therapy via either standard or intensified regimen, had pre-infusion trough levels measured by ELISA at the time of 3rd dose. An algorithm incorporating this trough level and the interval between doses 2 and 3 was used to determine timing and dose of first maintenance infusion, aiming to provide a trough level of 5–10 ug/mL when tested before dose 4. Induction regimens were at the discretion of the treating physician, but often intensified among patients with severe UC. Influence of patient demographics and baseline clinical disease activity (physician global assessment and wPCDAI or PUCAI) on early trough levels were assessed. From May to October 2016 at 6 participating sites, 77 children (mean age 12.4 years, 57% male, 53% CD, 47% UC/IBD-U) received 3-dose infliximab induction. CD patients were infused in standard fashion at weeks 0, 2, 6 with a mean dose of 5.5mg/kg/dose and concomitant immunomodulation (93% methotrexate; 7 % azathioprine); median pre-dose 3 IFX level was 11.9ug/ml (IQR: 8.5–27.2). UC/IBD-U patients (18% steroid-dependent, 82% steroid-refractory) received more drug (mean 6.8mg/kg/dose across 3 doses) and via an intensified regimen in 34%. Pre-dose 3 IFX levels (median 13.5ug/ml;IQR: 4.9–24.3) were comparable to CD despite higher dosing. 25% of UC/IBD-U patients vs. 11% of CD patients had infliximab trough level <5 ug/ml at time of dose 3. Variability in infliximab exposure is evident during induction. Patients with UC cleared drug more rapidly, requiring higher weight-based dosing and a more intensive regimen to achieve comparable drug levels post induction. Ongoing monitoring of trough levels measured prior to dose 4 in this cohort will determine whether early TDM with personalized dosing more consistently ensures adequate drug exposure with subsequent better clinical outcome. None
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it