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Record W4281388536 · doi:10.1053/j.gastro.2022.05.029

Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease

2022· article· en· W4281388536 on OpenAlexafffund
Arthur Mortha, Romain Remark, Diane M. Del Valle, Ling-Shiang Chuang, Zhi Chai, Inês Alves, Catarina M. Azevedo, Joana Gaifem, J.P. Martin, Francesca Petralia, Kevin Tuballes, Vanessa Barcessat, Siu Ling Tai, Hsin-Hui Huang, Ilaria Laface, Yeray Arteaga Jerez, Gilles Boschetti, Nicole Villaverde, Mona D. Wang, Ujunwa Korie, Joseph Murray, Rok-Seon Choung, Takahiro Sato, Renée M. Laird, Scott E. Plevy, Adeeb Rahman, Joana Torres, Chad Porter, Mark S. Riddle, Ephraim Kenigsberg, Salomé S. Pinho, Judy H. Cho, Miriam Mérad, Jean‐Frédéric Colombel, Sacha Gnjatic

Bibliographic record

VenueGastroenterology · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsUniversity of Toronto
FundersU.S. Army Medical Research Acquisition ActivityJanssen PharmaceuticalsJanssen Research and DevelopmentNational Cancer InstitutePfizerNatural Sciences and Engineering Research Council of CanadaTakeda CanadaCanadian Institutes of Health ResearchU.S. NavyGenentechFundação para a Ciência e a TecnologiaFerring PharmaceuticalsNational Institutes of HealthCanada Research ChairsGovernment of South AustraliaCrohn's and Colitis FoundationLeona M. and Harry B. Helmsley Charitable TrustNaval Medical Research CenterSanford J. Grossman Charitable TrustU.S. Department of DefenseNational Institute of Diabetes and Digestive and Kidney DiseasesSanofiShireBristol-Myers SquibbCrohn's and Colitis Foundation of AmericaUniversity of TorontoKenneth Rainin FoundationAbbVie CanadaBoehringer Ingelheim
KeywordsGranulocyte macrophage colony-stimulating factorMedicineGranulocyteGranulocyte macrophage colony-stimulating factor receptorImmunologyMacrophageColony-stimulating factorAutoantibodyMacrophage colony-stimulating factorAntibodyBiologyCytokineHaematopoiesisIn vitro

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.030
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.254
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations64
Published2022
Admission routes2
Has abstractno

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