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Expert consensus recommendations on the use of randomized clinical trials for drug approval in psychiatry- comparing trial designs

2022· article· en· W4281615567 on OpenAlexaff
Miriam von Mücke Similon, Cecilia Paasche, Fas J. Krol, Bernard Lerer, Guy M. Goodwin, Michael Berk, Andreas Meyer‐Lindenberg, Terence A. Ketter, Lakshmi N. Yatham, Joseph F. Goldberg, Gin S. Malhi, Rif S. El‐Mallakh, Rasmus Wentzer Licht, Allan H. Young, Flávio Kapczinski, Marnina Swartz, Michal Hagin, Carla Torrent, Alessandro Serretti, Ayşegül Yildiz, Anabel Martínez‐Arán, Sergio Strejilevich, Janusz Rybakowski, Gabriele Sani, Heinz Grunze, Gustavo Vázquez, Ana Gonzales Pinto, J.-M. Azorin, Willem A. Nolen, Othman Sentissi, Carlos López‐Jaramillo, Benício N. Frey, Andrew A. Nierenberg, Gordon Parker, David J. Bond, Adam F. Cohen, Alfonso Tortorella, Giulio Perugi, Eduard Vieta, Dina Popović

Bibliographic record

VenueEuropean Neuropsychopharmacology · 2022
Typearticle
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsSt. Joseph’s Healthcare HamiltonMcMaster UniversityQueen's UniversityUniversity of British Columbia
FundersNational Institute for Health and Care Research
KeywordsClinical trialMedicineRandomized controlled trialPlaceboAlternative medicineDelphi methodFamily medicineMEDLINEPsychiatrySurgeryInternal medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.566
metaresearch head score (Gemma)0.720
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.434
Threshold uncertainty score0.536

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.5660.720
Meta-epidemiology (narrow)0.0050.007
Meta-epidemiology (broad)0.0190.037
Bibliometrics0.0130.009
Science and technology studies0.0050.015
Scholarly communication0.0160.011
Open science0.0300.010
Research integrity0.0440.052
Insufficient payload (model declined to judge)0.0160.009

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.803
GPT teacher head0.555
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designTheoretical or conceptual
DomainMethods
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations16
Published2022
Admission routes1
Has abstractno

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