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Record W4282833430 · doi:10.1016/s2213-2600(22)00044-3

Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19

2022· review· en· W4282833430 on OpenAlexaff
Jonathan D. Casey, Laura M. Beskow, Jeremy Brown, Samuel M. Brown, Étienne Gayat, Michelle N. Gong, Michael O. Harhay, Samir Jaber, Jacob C. Jentzer, Pierre‐François Laterre, John C. Marshall, Michael A. Matthay, Todd W. Rice, Yves Rosenberg, Alison E. Turnbull, Lorraine B. Ware, Wesley H. Self, Alexandre Mebazaa, Sean P. Collins

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2022
Typereview
Languageen
FieldEconomics, Econometrics and Finance
TopicHealth Systems, Economic Evaluations, Quality of Life
Canadian institutionsSt. Michael's Hospital
FundersNational Center for Advancing Translational SciencesAbbott DiagnosticsCenters for Disease Control and PreventionPatient-Centered Outcomes Research InstituteBaxter InternationalNational Heart, Lung, and Blood InstituteAgency for Healthcare Research and QualityU.S. Department of DefenseGilead SciencesBill and Melinda Gates FoundationNational Institutes of HealthU.S. Department of Health and Human Services
KeywordsMedicineClinical trialIntensive care medicineHydroxychloroquinePsychological interventionAlternative medicineClinical study designCoronavirus disease 2019 (COVID-19)MEDLINEResearch designMedical physicsNursingInternal medicinePathologyDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.056
metaresearch head score (Gemma)0.028
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.360
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0560.028
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0050.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.937
GPT teacher head0.624
Teacher spread0.313 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations49
Published2022
Admission routes1
Has abstractno

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