[Retracted] Effects of Modified Duhuo Jisheng Decoction Combined with Arthroscopic Surgery on Bone Metabolism, Oxidative Stress, and Serum TLR4 and TGF‐β1 in Patients with Knee Osteoarthritis
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Data;Concerns/Issues about Results and/or Conclusions;Concerns/Issues about Referencing/Attributions;Concerns/Issues about Peer Review;Investigation by Journal/Publisher;Investigation by Third Party;Paper Mill;Computer-Aided Content or Computer-Generated Content;Unreliable Results and/or Conclusions;
- Date
- 9/27/2023 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Objective . To analyze the effects of modified Duhuo Jisheng Decoction combined with arthroscopic surgery on bone metabolism, oxidative stress, and serum TLR4 and TGF‐ β 1 in patients with knee osteoarthritis (KOA). Methods . Prospectively select 82 patients with KOA from January 2020 to January 2022 in our hospital and divide them into the control group and observation group according to the random number table method, with 41 patients in each group. The control group was treated with arthroscopic surgery alone and routine anti‐infection after operation. The observation group was treated with Duhuo Jisheng Decoction on the basis of the treatment of the control group. The patients in the two groups were treated continuously for 4 weeks. The improvement of patients’ symptoms was evaluated by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Before treatment and 4 weeks after treatment, the scores of traditional Chinese medicine (TCM) symptoms, bone metabolism indicators (cartilage oligomeric matrix protein (COMP), collagen type II carboxy terminal peptide (ctx‐II), and matrix metalloproteinase‐3 (MMP‐3)), oxidative stress indicators (superoxide dismutase (SOD), glutathione peroxidase (GSHPx), malondialdehyde (MDA), nitric oxide (NO)), serum Toll‐like receptor 4 (TLR4), and transforming growth factor β (TGF‐ β ) level were compared between the two groups. Results . After treatment, the WOMAC score of the two groups decreased (42.45 ± 10.83) in the observation group and (67.81 ± 14.63) in the control group. The WOMAC score of the observation group was lower than that of the control group ( P < 0.05). After treatment, the levels of COMP, CTX‐II, and MMP‐3 in the two groups decreased, and the levels of COMP, CTX‐II, and MMP‐3 in the observation group were lower than those in the control group ( P < 0.05). After treatment, the levels of SOD and GSHPx increased, while the levels of MDA and NO decreased in the two groups. The levels of SOD and GSHPx in the observation group were higher than those in the control group, while the levels of MDA and NO were lower than those in the control group ( P < 0.05). After treatment, the TLR4 level in the observation group was lower than that of the control group, and the level of TGF‐ β in the observation group was higher than that of the control group ( P < 0.05). Conclusion . Compared with arthroscopic surgery alone, combined with modified Duhuo Jisheng Decoction can better alleviate the clinical symptoms of patients with KOA, improve their bone metabolism, oxidative stress indicators, and serum TLR4 and TGF‐ β 1 level, and reduce the inflammatory injury of knee joint.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Journal of Environmental and Public Health
- Topic
- Osteoarthritis Treatment and Mechanisms
- Field
- Medicine
- Canadian institutions
- —
- Funders
- —
- Keywords
- MedicineWOMACOsteoarthritisMalondialdehydeOxidative stressInternal medicineDecoctionNitric oxideGlutathione peroxidaseSuperoxide dismutaseGastroenterologySurgeryPathology
- Has abstract in OpenAlex
- yes