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Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis
Jorim J. Tielbeek, Emil Uffelmann, Benjamin Williams, Lucía Colodro‐Conde, Éloi Gagnon, Travis T. Mallard, Brandt Levitt, Philip R. Jansen, A Johansson, Hannah Sallis, Giorgio Pistis, Gretchen Saunders, Andrea G. Allegrini, Kaili Rimfeld, Bettina Konte, Marieke Klein, Annette M. Hartmann, Jessica E. Salvatore, Ilja M. Nolte, Ditte Demontis, Anni Malmberg, S. Alexandra Burt, Jeanne E. Savage, Karen Sugden, Richie Poulton, Kathleen Mullan Harris, Scott Vrieze, Matt McGue, William G. Iacono, Nina Roth Mota, Jonathan Mill, Joana Viana, Brittany L. Mitchell, José J. Morosoli, Till F. M. Andlauer, Isabelle Ouellet‐Morin, Richard E. Tremblay, Sylvana M. Côté, Jean‐Philippe Gouin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Michelle K. Lupton, Nicholas G. Martin, Bernice Porjesz, Victor Hesselbrock, Tatiana Foroud, Howard J. Edenberg, Yunlong Liu, Martin H. Plawecki, Samuel Kuperman, John R. Kramer, Jacquelyn L. Meyers, Chella Kamarajan, Ashwini K. Pandey, Laura J. Bierut, John Rice, Kathleen K. Bucholz, Marc A. Schuckit, Jay A. Tischfield, Ronald P. Hart, Laura Almasy, Alison Goate, Paul A. Slesinger, Denise M. Scott, Enrique Castelao, Katri Räikkönen, Johan G. Eriksson, Jari Lahti, Catharina A. Hartman, Albertine J. Oldehinkel, Harold Snieder, Hexuan Liu, Martin Preisig, Alyce M. Whipp, Eero Vuoksimaa, Yi Lu, Patrick Jern, Dan Rujescu, Ina Giegling, Teemu Palviainen, Jaakko Kaprio, K. Paige Harden, Marcus R. Munafò, Geneviève Morneau‐Vaillancourt, Robert Plomin, Essi Viding, Brian B. Boutwell, Fazil Alıev, Danielle M. Dick, Arne Popma, Stephen V. Faraone, Anders D. Børglum, Sarah E. Medland, Barbara Franke, Michel Boivin, Jean‐Baptiste Pingault, Jeffrey Glennon, J. C. Barnes, Simon E. Fisher, Terrie E. Moffitt, Avshalom Caspi, Tinca J. C. Polderman, Daniëlle Posthuma
Bibliographic record
VenueMolecular Psychiatry · 2022
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsCentre Hospitalier Universitaire Sainte-JustineUniversité du Québec à MontréalConcordia UniversityUniversité de MontréalUniversité LavalResearch Unit on Children's Psychosocial Maladjustment
FundersNational Health and Medical Research CouncilHorizon 2020 Framework ProgrammeNational Institute of Mental HealthFonds de Recherche du Québec-Société et CultureNational Institutes of HealthH. Lundbeck A/SNational Institute on Alcohol Abuse and AlcoholismSuomen TiedeseuraSigne ja Ane Gyllenbergin SäätiöJuho Vainion SäätiöUniversity of BristolEuropean CommissionNational Institute for Health and Care ResearchMedical Research CouncilYrjö Jahnssonin SäätiöQIMR Berghofer Medical Research InstituteNederlandse Organisatie voor Wetenschappelijk OnderzoekWellcome TrustLundbeckfondenNational Institute on Drug AbuseUniversity Hospitals Bristol NHS Foundation TrustJalmari ja Rauha Ahokkaan Säätiö
KeywordsGenetic architectureHeritabilityAntisocial personality disorderGenome-wide association studyPsychologyGeneticsPleiotropyAggressionPsychopathyGenetic correlationSingle-nucleotide polymorphismQuantitative trait locusClinical psychologyGenetic variationGenotypeDevelopmental psychologyBiologyPoison controlMedicineGenePersonalityInjury preventionPhenotype
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.579
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.005 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.039
GPT teacher head0.332
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
Study designMeta-analysis
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations63
Published2022
Admission routes2
Has abstractno