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Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Kiran Samra, Amy MacDougall, Arabella Bouzigues, Martina Bocchetta, David M. Cash, Caroline Greaves, Rhian S. Convery, John C. van Swieten, Harro Seelaar, Lize C. Jiskoot, Fermín Moreno, Raquel Sánchez‐Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Christopher Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan D. Rohrer, Lucy L. Russell, Annabel Nelson, David L. Thomas, Emily Todd, Hanya Benotmane, Jennifer Nicholas, Rachelle Shafei, Carolyn Timberlake, Thomas Cope, Timothy Rittman, Alberto Benussi, Enrico Premi, Roberto Gasparotti, Silvana Archetti, Stefano Gazzina, Valentina Cantoni, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Vittoria Borracci, Giacomina Rossi, Giorgio Giaccone, Giuseppe Di Fede, Paola Caroppo, Sara Prioni, Veronica Redaelli, David F. Tang‐Wai, Ekaterina Rogaeva, Miguel Castelo‐Branco, Morris Freedman, Ron Keren, Sandra E. Black, Sara Mitchell, Christen Shoesmith, Rosa Rademakers, Jackie M. Poos, Janne M. Papma, Lucia Giannini, Rick van Minkelen, Yolande A.L. Pijnenburg, Benedetta Nacmias, Camilla Ferrari, Cristina Polito, Gemma Lombardi, Valentina Bessi, Michele Veldsman, Christin Andersson, Håkan Thonberg, Linn Öijerstedt, Vesna Jelić, Paul Thompson, Tobias Langheinrich, Albert Lladó, Anna Antonell, Jaume Olives, Mircea Balasa, Núria Bargalló, Sergi Borrego‐Écija, Ana Verdelho, Carolina Maruta, Catarina B. Ferreira, Gabriel Miltenberger, Frederico Simões do Couto, Alazne Gabilondo, Ana Gorostidi, Jorge Villanúa, Marta Cañada, Mikel Tainta, Miren Zulaica, Myriam Barandiarán, Patricia Alves, Benjamin Bender, Carlo Wilke, Lisa Graf, Annick Vogels, Mathieu Vandenbulcke, Philip Van Damme, Rose Bruffaerts, Koen Poesen, Pedro Rosa‐Neto, Serge Gauthier, Agnès Camuzat, Alexis Brice, Anne Bertrand, Aurélie Funkiewiez, Daisy Rinaldi, Dario Saracino, Olivier Colliot, Sabrina Sayah, Catharina Prix, Elisabeth Wlasich, Olivia Wagemann, Sandra Loosli, Sonja Schönecker, Tobias Hoegen, Jolina Lombardi, Sarah Anderl‐Straub, Adeline Rollin, Grégory Kuchcinski, Maxime Bertoux, Thibaud Lebouvier, Vincent Deramecourt, Beatriz Santiago, Diana Duro, Maria João Leitão, Maria Rosário Almeida, Miguel Tábuas‐Pereira, Sónia Afonso
Bibliographic record
VenueJournal of Neurology · 2022
Typearticle
Languageen
FieldMedicine
TopicAmyotrophic Lateral Sclerosis Research
Canadian institutionsMcGill UniversityWestern UniversityMontreal Neurological Institute and HospitalUniversity of TorontoOccupational Cancer Research CentreHealth Sciences CentreMcGill University Health CentreSunnybrook Health Science CentreUniversité Laval
FundersNIHR Cambridge Biomedical Research CentreInstituto de Salud Carlos IIIMedical Research CouncilTau ConsortiumUK Dementia Research InstituteStichting DioraphteNetworks of Centres of Excellence of CanadaFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaUniversità degli Studi di BresciaStockholms Läns LandstingUniversidade de CoimbraUniversity of TorontoNederlandse Organisatie voor Wetenschappelijk OnderzoekAlzheimer's SocietyAlzheimer SocietyMinistero della SaluteToronto Rehabilitation InstituteCentro de Investigación Biomédica en Red sobre Enfermedades NeurodegenerativasWolfson FoundationWellcome TrustUniversity College LondonUniversity of CambridgeBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchKarolinska InstitutetWeston Brain InstituteZonMwBrain Research UKAlzheimer's Research TrustNational Brain AppealAgence Nationale de la RechercheDeutsche ForschungsgemeinschaftUniversity Health NetworkUniversità degli Studi di MilanoEU Joint Programme – Neurodegenerative Disease ResearchAlzheimer NederlandSunnybrook Research InstituteFundació la Marató de TV3Canadian Institutes of Health ResearchLondon School of Hygiene and Tropical Medicine
KeywordsFrontotemporal dementiaPsychologyPrimary progressive aphasiaAudiologyBoston Naming TestC9orf72Verbal fluency testAphasiaFluencyDementiaNeuropsychologyCognitive psychologyMedicinePathologyNeuroscienceCognitionDisease
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.030
Threshold uncertainty score0.576
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.033
GPT teacher head0.295
Teacher spread0.262 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations13
Published2022
Admission routes2
Has abstractyes