← Back to cohort
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami I. Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiří Bártek, Nicolás G. Bazán, Christoph Becker, Francesca Bernassola, Mathieu J.M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Brož, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona‐Gutiérrez, Francesco Cecconi, Francis Ka-Ming Chan, Guoqiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos‐Ruiz, Peter E. Czabotar, Vincenzo D’Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus‐Michael Debatin, Ralph J. DeBerardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian David Dynlacht, Wafik S. El‐Deiry, John W. Elrod, Kurt Engeland, Gian María Fimia, Claudia Galassi, Carlo Ganini, Ana J. García‐Sáez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala‐Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth M. Kluck, Dmitri V. Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otı́n, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean‐Christophe Marine, Séamus J. Martin, Jean‐Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Muñoz‐Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H.M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean‐Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecília M. P. Rodrigues, Barak Rotblat, Carla V. Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe Sica, John Silke, Hans‐Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, György Szabadkai, Stephen W. G. Tait, Daolin Tang, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang‐Tian Yang, Zahra Zakeri, Joanna Zawacka‐Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
Bibliographic record
VenueCell Death and Differentiation · 2023
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCell death mechanisms and regulation
Canadian institutionsMemorial University of NewfoundlandUniversity of British ColumbiaSunnybrook HospitalUniversity of Toronto
FundersNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Allergy and Infectious DiseasesNational Institute of General Medical SciencesOffice of Defense ProgramsBeatson Institute for Cancer ResearchUniversitätsmedizin der Johannes Gutenberg-Universität MainzCambridge Institute for Medical Research, University of CambridgeBiotechnology and Biological Sciences Research CouncilMedical Research CouncilUniversity of Texas MD Anderson Cancer CenterLabEx DEvweCANUniversité de ParisCentre Léon BérardRede de Química e TecnologiaCancer Center AmsterdamNational University Health SystemSouthern Medical UniversityNovo Nordisk FondenAmsterdam University Medical CentersKarolinska InstitutetAssociazione Italiana per la Ricerca sul CancroUniversität StuttgartKarl-Franzens-Universität GrazUniversité de LyonJulius-Maximilians-Universität WürzburgSorbonne UniversitéUK Dementia Research InstituteSoochow UniversityStony Brook UniversityUniversité de GenèveUniversidad de OviedoThomas Jefferson UniversityUniversità degli Studi dell'AquilaMedizinische Universität GrazPeking Union Medical CollegeUniversity of BernUniversidad de ChileLeukemia and Lymphoma SocietyUniversidade de LisboaUniversità Cattolica del Sacro CuoreBoard of the Swiss Federal Institutes of TechnologyCentre National de la Recherche ScientifiqueOncode InstituteUniversità degli Studi dell'InsubriaUniversity of TokyoConsejo Nacional de Investigaciones Científicas y TécnicasUniversiteit GentWeill Cornell Medical CollegeYork UniversityState Key Laboratory of Radiation Medicine and ProtectionCity University of New YorkRoyal College of Surgeons in IrelandLigue Contre le CancerUniversity of LeicesterInstitut Gustave-RoussyYale UniversityCompagnia di San PaoloTechnische Universität DresdenUniversiteit van AmsterdamÖsterreichischen Akademie der WissenschaftenInstitut Universitaire de FranceUniversity of South AustraliaDirectorate for Biological SciencesNational Center for Advancing Translational SciencesUniversity of AdelaideUniversitat Pompeu FabraInstitut National de la Santé et de la Recherche MédicaleJohns Hopkins UniversityAgence Nationale de la RechercheFaculty of Health and Medical Sciences, University of Western AustraliaU.S. Department of DefenseCancer Research UKLa Trobe UniversityNational University of SingaporeUniversity of QueenslandChinese Academy of SciencesUniversità degli Studi di Roma Tor VergataSt. John's UniversityUniversity of SouthamptonStand Up To CancerUniversidade do PortoNorthwestern UniversityUniversity of GlasgowChinese Academy of Medical SciencesSanofiUniversità degli Studi di MilanoBuck Institute for Research on AgingUniversity of WashingtonQueens College, City University of New YorkDipartimento di Medicina e Chirurgia, Università degli Studi di Milano-BicoccaNYU Grossman School of MedicineNational Institute on AgingUniversity of BathUniversität zu KölnUniversità degli Studi di PadovaUniversity of California, San DiegoPeter MacCallum Cancer CentreJohns Hopkins Bloomberg School of Public HealthLaboratório Associado para a Química VerdeNational Cancer InstituteKU LeuvenUniversity of South CarolinaUniversity of MichiganSt. Jude Children's Research HospitalNational Natural Science Foundation of ChinaCincinnati Children's Hospital Medical CenterCancer Research InstituteNational Institutes of Health
KeywordsApoptosisProteasesProgrammed cell deathContext (archaeology)BiologyHomeostasisCarcinogenesisDiseaseCaspaseCell biologyCellEmbryonic stem cellImmunologyNeurosciencePathologyMedicineCancerGeneticsGeneBiochemistry
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.013
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.061
GPT teacher head0.290
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations351
Published2023
Admission routes2
Has abstractno