Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: none
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.747
- Threshold uncertainty score
- 0.607
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.305 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- The Journal of Experimental Medicine
- Topic
- Mosquito-borne diseases and control
- Field
- Medicine
- Canadian institutions
- not available
- Funders
- National Center for Advancing Translational SciencesNational Institutes of HealthMinistero della DifesaFondation Bettencourt SchuellerMinistero della SaluteMinistère de l'Education Nationale, de l'Enseignement Superieur et de la RechercheEuropean Society for ImmunodeficienciesHospital for Sick ChildrenNational Institute of Allergy and Infectious DiseasesFisher Center for Alzheimer's Research FoundationAgence Nationale de la RechercheUniversità degli Studi di PaviaAssistance Publique - Hôpitaux de ParisEuropean CommissionSCOR Corporate Foundation for ScienceInstitut des maladies génétiques ImagineMinistère de l'Enseignement supérieur, de la Recherche et de l'InnovationAssistance publique-Hôpitaux de ParisMeyer FoundationRockefeller UniversityInstitut National de la Santé et de la Recherche MédicaleFondation du SouffleHorizon 2020 Framework ProgrammeOpen Square FoundationFondation pour la Recherche MédicaleJPB FoundationGeorgia Clinical and Translational Science AllianceHoward Hughes Medical InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesFondazione IRCCS Policlinico San MatteoUniversità degli Studi di PadovaSt. Giles Foundation
- Keywords
- EncephalitisVirologyNeutralizing antibodyJapanese encephalitisAntibodyPopulationVero cellMedicineFlavivirusAutoantibodyImmunologyTiterVirus
- Has abstract in OpenAlex
- yes