MétaCan
Menu
Back to cohort
Record W4384616215 · doi:10.1080/13506129.2023.2229484

Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay

2023· article· en· W4384616215 on OpenAlexaffabout
Teresa Coelho, Angela Dispenzieri, Martha Grogan, Isabel Conceição, Márcia Waddington‐Cruz, Arnt V. Kristen, Jonas Wixner, Igor Diemberger, Juan González‐Moreno, Mathew S. Maurer, Violaine Planté‐Bordeneuve, Pablo García‐Pavía, Ivailo Tournev, José González‐Costello, Eve Cariou, Alejandra González‐Duarte, Oliver Glass, Doug Chapman, Leslie Amass, Anna Hüsing‐Kabar, Brian Drachman, Fábio Barroso, Mitsuharu Ueda, Yoshiki Sekijima, Anna Mazzeo, Luca Gentile, Eun‐Seok Jeon, David Slosky, Marco Luigetti, Mazen Hanna, Miriam Freimer, Francisco Muñoz-Beamud, David Adams, Henning Mølgaard, Rayomand Press, Hans Nienhuis, Calogero Lino Cirami, Michele Emdin, Edward J. Miller, Josep Maria Campistol Plana, Jocelyn Inamo, Dianna Quan, Scott L. Hummel, Amir Dori, Ronald Witteles, Sanjiv J. Shah, Daniel J. Lenihan, Olga Azevedo, Cheng‐Yin Tan, Srinivas Murali, Saša Živković, Edileide de Barros Correia, José Nativi Nicolau, José Tallaj, Nowell M. Fine, Carsten Tschöpe, Roberto Fernández‐Torrón, Michael Polydefkis, Laura Obici, Sorina Bădeliță, Stephen S. Gottlieb, James M. Tauras, Hector Ventura, Robert Brunkhorst, Felix Darstein, Jeeyoung Oh, Tessa Marburger, Christopher R. Mueller, Johan Van Cleemput, Valeria Salutto, Yeşim Parman, Chi‐Chao Chao, N. Sarswat, Alberta L. Warner, D. Eric Steidley, Jeffrey Ralph, William Cotts, James E. Hoffman, Marcelo Rugiero, Sonoko Misawa, José Luís Muñoz-Blanco, Lucía Galán Dávila, Menachem Sadeh, Jin Luo, Theodoros Kyriakides, Annabel Wang, Horacio Kaufmann

Bibliographic record

VenueAmyloid · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAmyloidosis: Diagnosis, Treatment, Outcomes
Canadian institutionsFoothills Medical CentreUniversity of Alberta
FundersDaiichi Sankyo EuropeVA Greater Los Angeles Healthcare SystemUniversity of California, IrvineSchool of Medicine, Vanderbilt UniversityAarhus UniversitetFleniUniversità degli Studi di MessinaSamsungKonkuk UniversityCleveland ClinicChiba UniversityRWTH Aachen UniversityAlnylam PharmaceuticalsNational Taiwan UniversityNational Taiwan University HospitalKonkuk University Medical CenterProthenaBoston Scientific CorporationTemple UniversitySanofiSungkyunkwan UniversityCleveland Clinic FoundationPfizerUniversity of MiamiCelgeneUniversity of PennsylvaniaVanderbilt UniversityAarhus Universitetshospital
KeywordsTransthyretinAmyloidosisMedicineInternal medicine

Abstract

fetched live from OpenAlex

Transthyretin amyloidosis (ATTR amyloidosis) is a progressive disease characterised by amyloid fibril deposits in the peripheral nerves, heart and other tissues and organs [1]. ATTR amyloidosis is ...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.011
Threshold uncertainty score0.022

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.244
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2023
Admission routes2
Has abstractyes

Explore more

Same venueAmyloidSame topicAmyloidosis: Diagnosis, Treatment, OutcomesFrench-language works237,207