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Record W4387300006 · doi:10.21203/rs.3.rs-3258813/v1

Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study

2023· preprint· en· W4387300006 on OpenAlexaff
John R. Kelsoe, Anna Ou, Sara Brin Rosenthal, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Martin Alda, Azmeraw T. Amare, Raffaella Ardau, Bárbara Arias, Jean‐Michel Aubry, Lena Backlund, Cláudio E. M. Banzato, Michael Bauer, Bernhard T. Baune, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Bhattacharjee Abesh, Joanna M. Biernacka, Elise T. Bui, Pablo Cervantes, Guo‐Bo Chen, Hsi‐Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Francesc Colom, David A. Cousins, Cristiana Cruceanu, Piotr M. Czerski, Clarissa de Rosalmeida Dantas, Alexandre Dayer, Franziska Degenhardt, J. Raymond DePaulo, Bruno Étain, Peter Falkai, Frederike T. Fellendorf, Ewa Ferensztajn‐Rochowiak, Andreas J. Forstner, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Sébastien Gard, Julie Garnham, Fernando S. Goes, Maria Grigoroiu‐Serbânescu, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Stéphane Jamain, Esther Jiménez, Jean‐Pierre Kahn, Layla Kassem, Tadafumi Kato, Sarah Kittel‐Schneider, Barbara König, Po‐Hsiu Kuo, Ichiro Kusumi, Nina Dalkner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Carlos López‐Jaramillo, Glenda MacQueen, Mario Maj, Mirko Manchia, Cynthia Marie‐Claire, Lina Martinsson, Manuel Mattheisen, Michael J. McCarthy, Susan L. McElroy, Francis J. McMahon, Philip B. Mitchell, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomáš Novák, Urban Ösby, Norio Ozaki, Sergi Papiol, Roy H. Perlis, Andrea Pfennig, James B. Potash, Daniela Reich‐Erkelenz, Andreas Reif, Eva Z. Reininghaus, Marcella Rietschel, Guy A. Rouleau, Janusz Rybakowski, Martin Schalling, Peter R. Schofield, Klaus Oliver Schubert, Thomas G. Schulze, Barbara Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Kazutaka Shimoda, Christian Simhandl, Claire Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopková, Sarah K. Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie H. Witt, Naomi R. Wray, A. Jordan Wright, Trevor M. Young, Peter P. Zandi, Maria Del Zompo

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldMedicine
TopicBipolar Disorder and Treatment
Canadian institutionsDouglas Mental Health University InstituteMcGill UniversityMcGill University Health CentreDalhousie University
FundersMedical Research CouncilAlfried Krupp von Bohlen und Halbach-StiftungNational Institute of Mental HealthVetenskapsrådetDeutsche ForschungsgemeinschaftUniversity of California, San DiegoRheinische Friedrich-Wilhelms-Universität BonnBundesministerium für Bildung und ForschungNational Alliance for Research on Schizophrenia and DepressionNational Health and Medical Research CouncilKarolinska InstitutetBrain and Behavior Research Foundation
KeywordsReplication (statistics)Lithium (medication)PI3K/AKT/mTOR pathwayFocal adhesionBipolar disorderProtein kinase BComputational biologyBiologyPsychologyCell biologyPsychiatryVirologySignal transduction

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.026

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.009
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0010.002
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.088
GPT teacher head0.408
Teacher spread0.319 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2023
Admission routes1
Has abstractno

Explore more

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