DISTINCT EFFECTS OF THE Β2-ADRENERGIC AGONIST FORMOTEROL AND THE CHOLINESTERASE INHIBITOR PYRIDOSTIGMINE IN A NEW MURINE MYASTHENIA MODEL WITH SPECIFIC VACHT DELETION IN MOTOR NEURONS
Bibliographic record
Abstract
Introduction: muscle contraction is controlled by motoneurons by releasing vesicles filled with acetylcholine (ACh) by the vesicular ACh transporter (VAChT). Alterations in ACh release can promote muscle weakness, as seen in Congenital Myasthenic Syndromes (CMS). Here, we present an innovative mice model for CMSs, with specific VAChT deletion in α-motorneurons (mnVAChT-KD). Cholinesterase inhibitors drugs, such as pyridostigmine (PYR), are the classical pharmacological treatment for CMSs, however, recently, β2-adrenergic agonists such as formoterol (FOR) have been reported as a new pharmacological approach for CMSs treatment
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".