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Record W4388379358 · doi:10.1016/j.jaci.2023.10.018

JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study

2023· article· en· W4388379358 on OpenAlexaff
Marco Fischer, Peter Olbrich, Jérôme Hadjadj, V. Aumann, Shahrzad Bakhtiar, Vincent Barlogis, Philipp von Bismarck, Markéta Bloomfield, Claire Booth, Emmeline P. Buddingh, Deniz Çağdaş, Martin Castelle, Alice Chan, Shanmuganathan Chandrakasan, Kritika Chetty, Pierre Cougoul, Étienne Crickx, Jasmeen Dara, Àngela Deyà‐Martínez, Susan Farmand, Renata Formánková, Andrew R. Gennery, Luis Ignacio González‐Granado, David Hagin, Leif G. Hanitsch, Jana Hanzlı́ková, Fabian Hauck, J. Ivorra Cortés, Kai Kisand, Ayça Kıykım, Julia Körholz, Timothy Ronan Leahy, Joris van Montfrans, Zohreh Nademi, Brigitte Nelken, Suhag Parikh, Silvi Plado, Jan Ramakers, Antje Redlich, Frédéric Rieux‐Laucat, Jacques G. Rivière, Yulia Rodina, Pérsio Roxo Júnior, Sarah Salou, Catharina Schuetz, Anna Shcherbina, Mary Slatter, Fabien Touzot, Ekrem Ünal, Arjan C. Lankester, Siobhan O. Burns, Mikko Seppänen, Olaf Neth, Michael H. Albert, Stephan Ehl, Bénédicte Neven, Carsten Speckmann

Bibliographic record

VenueJournal of Allergy and Clinical Immunology · 2023
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunodeficiency and Autoimmune Disorders
Canadian institutionsUniversité de Montréal
FundersMedizinische Fakultät der Albert-Ludwigs-Universität FreiburgBundesministerium für Bildung, Wissenschaft, Forschung und TechnologieIstanbul Üniversitesi-CerrahpasaLastentautien TutkimussäätiöInstituto de Salud Carlos IIIElse Kröner-Fresenius-StiftungKinderspital ZürichBundesministerium für Bildung und ForschungSanofiTechnische Universität DresdenDeutsche Forschungsgemeinschaft
KeywordsstatMedicineJAK-STAT signaling pathwayPharmacologyCancer researchOncologyInternal medicineSignal transductionBiologyGeneticsReceptorTyrosine kinaseSTAT3

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.343
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations61
Published2023
Admission routes1
Has abstractno

Explore more

Same venueJournal of Allergy and Clinical ImmunologySame topicImmunodeficiency and Autoimmune DisordersFrench-language works237,207