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Record W4391101037 · doi:10.1001/jamaneurol.2023.5319

Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

2024· article· en· W4391101037 on OpenAlexaff
Nicholas J. Ashton, Wagner S. Brum, Guglielmo Di Molfetta, Andréa Lessa Benedet, Burak Arslan, Erin M. Jonaitis, Rebecca E. Langhough, Karly Alex Cody, Rachael E. Wilson, Cynthia M. Carlsson, Eugeen Vanmechelen, Laia Montoliu‐Gaya, Juan Lantero‐Rodriguez, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick A. Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa‐Neto, Sterling C. Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterberg

Bibliographic record

VenueJAMA Neurology · 2024
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-MontréalCentre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-JeanMcGill UniversityDouglas Mental Health University Institute
FundersNational Institute on Aging
KeywordsMedicineCohortBiomarkerDementiaCohort studyInternal medicineAlzheimer's diseaseOncologyTau proteinAlzheimer's Disease Neuroimaging InitiativeMagnetic resonance imagingPositron emission tomographyPathologyDiseaseNuclear medicineRadiology

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.020

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.010
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.322
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations768
Published2024
Admission routes1
Has abstractyes

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