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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
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fundA Canadian funder is recorded on the work.
VenuemedRxiv · 2024
Typepreprint
Languageen
FieldPsychology
TopicObsessive-Compulsive Spectrum Disorders
Canadian institutionsUniversity of CalgaryBC Mental Health & Substance Use ServicesHealth Sciences CentreSunnybrook Health Science CentreMcMaster UniversityBC Children's HospitalDalhousie UniversityUniversity of TorontoCentre for Addiction and Mental HealthUniversity of British ColumbiaHospital for Sick Children
FundersNational Center for Advancing Translational SciencesNational Center for Research ResourcesNational Institute of Mental HealthFaculty of Medicine and Health, University of SydneyInstituto de Salud Carlos IIINational Health and Medical Research CouncilNIHR Maudsley Biomedical Research CentreMindich Child Health and Development Institute, Icahn School of Medicine at Mount SinaiCereal Partners WorldwideDepartment of Psychiatry, University of TorontoStanley Center for Psychiatric Research, Broad InstituteSUNY Downstate Medical CenterUniversity of North Carolina at Chapel HillNational Institutes of HealthNational Institute on AgingFundació Institut de Recerca Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaEuropean College of NeuropsychopharmacologyCentro de Investigación Biomédica en Red de Salud MentalNorwegian Institute of Public HealthHumboldt-Universität zu BerlinCampbell Family Mental Health Research InstituteHelse Midt-NorgeNovo NordiskBundesministerium für Bildung und ForschungUniversiteit van AmsterdamEuropean CommissionEuropean Regional Development FundKing's College LondonDepartment of Health and Social CareOntario Council on Graduate Studies, Council of Ontario UniversitiesMinistero dell’Istruzione, dell’Università e della RicercaNorges ForskningsrådQIMR Berghofer Medical Research InstituteAmsterdam University Medical CentersUniversidade de Santiago de CompostelaHelse- og OmsorgsdepartementetNational Center for PTSD, U.S. Department of Veterans AffairsDeutsche ForschungsgemeinschaftNorges Teknisk-Naturvitenskapelige UniversitetStichting Volksbond RotterdamNIH Clinical CenterTrond Mohn stiftelseFundación Instituto de Investigación Sanitaria de Santiago de CompostelaMcMaster UniversityMinisterio de Ciencia, Innovación y UniversidadesVetenskapsrådetRoy J. and Lucille A. Carver College of Medicine, University of IowaInstituto de Investigación Sanitaria de Santiago de CompostelaGeorgia Clinical and Translational Science AllianceStockholms Läns LandstingAarhus UniversitetVanderbilt University Medical CenterAarhus UniversitetshospitalBeatrice and Samuel A. Seaver FoundationMedical Research CouncilTartu ÜlikoolFundació la Marató de TV3Johns Hopkins UniversityFP7 HealthUniversity of TorontoOffice of Research and DevelopmentKarolinska InstitutetYale UniversityU.S. Department of Veterans AffairsAgència de Gestió d'Ajuts Universitaris i de RecercaNational Institute for Health and Care ResearchLundbeckfondenCenter for Innovative MedicineState University of New YorkH. Lundbeck A/SHospital for Sick ChildrenForskningsrådet om Hälsa, Arbetsliv och VälfärdBroad InstituteAFA FörsäkringMcLean HospitalVanderbilt UniversityMinistero della SaluteInternational OCD FoundationMassachusetts General Hospital
KeywordsGenome-wide association studyAssociation (psychology)Obsessive compulsiveGeneticsBiologyPsychologyPsychiatrySingle-nucleotide polymorphismGenotypeGenePsychotherapist
Abstract
fetched live from OpenAlexAbstract Obsessive-compulsive disorder (OCD) affects ∼1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3, CTNND1 and multiple genes in the MHC region. We estimated that ∼11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all of the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa, and Tourette syndrome, and was negatively associated with inflammatory bowel diseases, educational attainment, and body mass index.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.038
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Teacher spread0.313 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
