← Back to cohort
Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder
Natalie C. W. Ho, Richard A. I. Bethlehem, Jakob Seidlitz, Nikita Nogovitsyn, Paul D. Metzak, Pedro L. Ballester, Stefanie Hassel, Susan Rotzinger, Jordan Poppenk, Raymond W. Lam, Valerie H. Taylor, Roumen Milev, Chris Adamson, Sophie Adler, Aaron Alexander‐Bloch, Evdokia Anagnostou, Kevin Anderson, Ariosky Areces-González, Duncan E. Astle, Bonnie Auyeung, Muhammad Ayub, Jong Bin Bae, Gareth Ball, Simon Baron‐Cohen, Richard Beare, Saashi A. Bedford, Vivek Benegal, Frauke Beyer, John Blangero, Manuel Blesa, James P. Boardman, Matthew Borzage, Jorge Bosch‐Bayard, Niall Bourke, Edward T. Bullmore, Vince D. Calhoun, M. Mallar Chakravarty, Christina Chen, Casey Chertavian, Gaël Chételat, Yap Seng Chong, Aiden Corvin, Manuela Costantino, Fabrice Crivello, Vanessa Cropley, Jennifer Crosbie, Nicolás Crossley, Marion Delarue, Richard Delorme, Sylvane Desrivières, Gabriel A. Devenyi, Maria A. Di Biase, Raymond J. Dolan, Kirsten A. Donald, Gary Donohoe, Lena Dorfschmidt, Katharine Dunlop, A. David Edwards, Jed T. Elison, Cameron T. Ellis, Jeremy A. Elman, Lisa T. Eyler, Damien A. Fair, Paul C. Fletcher, Peter Fonagy, Carol E. Franz, Lídice Galán‐Garcia, Ali Gholipour, Jay N. Giedd, John H. Gilmore, David C. Glahn, Ian M. Goodyer, P. Ellen Grant, Nynke A. Groenewold, Shreya Gudapati, Faith M. Gunning, Raquel E. Gur, Ruben C. Gur, Christopher Hammill, Oskar Hansson, Trey Hedden, Andreas Heinz, Richard N. Henson, Katja Heuer, Jacqueline Hoare, Bharath Holla, Avram J. Holmes, Hao Huang, Jonathan Ipser, Clifford R. Jack, Andrea Parolin Jackowski, Tianye Jia, David T. Jones, Peter B. Jones, René S. Kahn, Hasse Karlsson, Linnéa Karlsson, Ryuta Kawashima, Elizabeth Kelley, Silke Kern, Manfred G. Kitzbichler, William S. Kremen, François Lalonde, Brigitte Landeau, Jason P. Lerch, John D. Lewis, Jiao Li, Wei Liao, Conor Liston, Michael Lombardo, Jinglei Lv, Travis T. Mallard, Machteld Marcelis, Samuel R. Mathias, Bernard Mazoyer, Philip McGuire, Michael J. Meaney, Andrea Mechelli, Bratislav Mišić, Sarah E. Morgan, David Mothersill, Cynthia M. Ortinau, Rik Ossenkoppele, Minhui Ouyang, Lena Palaniyappan, Léo Paly, Pedro Mário Pan, Christos Pantelis, Min Tae M Park, Tomáš Paus, Zdenka Pausová, Deirel Paz-Linares, Alexa Pichet Binette, Karen Pierce, Xing Qian, Anqi Qiu, Armin Raznahan, Timothy Rittman, Amanda Rodrigue, Caitlin K. Rollins, Rafael Romero-García, Lisa Ronan, Monica D. Rosenberg, David H. Rowitch, Giovanni Abrahão Salum, Theodore D. Satterthwaite, H. Lina Schaare, Jenna Schabdach, Russell Schachar, Michael Schöll, Aaron P. Schultz, David Sharp, Russell T. Shinohara, Ingmar Skoog, Christopher D. Smyser, Reisa A. Sperling, Dan J. Stein, Aleks Stolicyn, John Suckling, Gemma Sullivan, Benjamin Thyreau, Roberto Toro, Nicolas Traut, Kamen A. Tsvetanov, Nicholas B. Turk‐Browne, Jetro J. Tuulari, Christophe Tzourio, Étienne Vachon‐Presseau, Mitchell Valdés-Sosa, Pedro A. Valdés‐Sosa, Sofie L. Valk, Thérèse van Amelsvoort, Simon Vandekar, Lana Vasung, Petra E. Vértes, Lindsay W. Victoria, Sylvia Villeneuve, Arno Villringer, Jacob W. Vogel, Konrad Wagstyl, Y. Wang, Simon K. Warfield, Varun Warrier, Eric Westman, Margaret L. Westwater, Heather C. Whalley, Simon R. White, A. Veronica Witte, Ning Yang, B.T. Thomas Yeo, Hyuk Jin Yun, Andrew Zalesky, Heather J. Zar, Anna Zettergren, Juan Zhou, Hisham Ziauddeen, Dabriel Zimmerman, André Zugman, Xi‐Nian Zuo, Benício N. Frey, Kate L. Harkness, Jean Addington, Sidney H. Kennedy
Bibliographic record
VenueBiological Psychiatry Cognitive Neuroscience and Neuroimaging · 2024
Typearticle
Languageen
FieldNeuroscience
TopicStress Responses and Cortisol
Canadian institutionsQueen's UniversityMcMaster UniversityKingston General HospitalProvidence Health CareSt Joseph's Health CentreUniversity of British ColumbiaSt. Joseph’s Healthcare HamiltonHospital for Sick ChildrenUniversity of CalgaryCentre for Global Health ResearchUniversity of Toronto
FundersJanssen CanadaNational Institute of Neurological Disorders and StrokeNational Institute of Mental HealthNational Institute on AgingNIHR Cambridge Biomedical Research CentreNational Social Science Fund of ChinaNational Medical Research CouncilEuropean CommissionDepartment of Psychiatry, University of TorontoKnut och Alice Wallenbergs StiftelseCanadian Institutes of Health ResearchNational Institute on Alcohol Abuse and AlcoholismMcKnight FoundationPfizerAvid RadiopharmaceuticalsNational Institute on Deafness and Other Communication DisordersMitacsVetenskapsrådetAllerganAgence Régionale de Santé Île-de-FranceInstitut National de la Santé et de la Recherche MédicaleH. Lundbeck A/SAgencia Nacional de Investigación y DesarrolloNational University Health SystemEmerson CollectiveJunta de AndalucíaGovernment of the United KingdomCanada First Research Excellence FundChina Postdoctoral Science FoundationBeijing Municipal Science and Technology CommissionConseil Régional AquitaineSingapore Institute for Clinical SciencesNational Heart, Lung, and Blood InstituteMax-Planck-GesellschaftVancouver Coastal Health Research InstituteUniversité de BordeauxRégion NormandieEuropean Regional Development FundJane ja Aatos Erkon SäätiöUniversity of TorontoOntario Mental Health FoundationFondazione CariploNational Natural Science Foundation of ChinaGovernment of OntarioBiogenVistagen TherapeuticsWellcome TrustAgence Nationale de la RechercheNational Research Foundation SingaporeNederlandse Organisatie voor Wetenschappelijk OnderzoekDeutsche ForschungsgemeinschaftNational Institute for Health and Care ResearchNational Research FoundationU.S. Department of DefenseCancer Research UKNational University of SingaporeSanofiEisaiBill and Melinda Gates FoundationLister Institute of Preventive MedicineUniversity of OxfordAlzheimerfondenIndian Council of Medical ResearchBeijing Normal UniversityNational Institute of Biomedical Imaging and BioengineeringDepartment of Health and Social CareMichael Smith Health Research BCNatural Sciences and Engineering Research Council of CanadaGuarantors of BrainNational Health and Medical Research CouncilAssociation France AlzheimerCompute CanadaFondation Vaincre AlzheimerEmil Aaltosen SäätiöU.S. Department of Veterans AffairsSuomen Lääketieteen SäätiöGW PharmaceuticalsNational Science FoundationTemple UniversityGenentechAmerican Academy of NeurologyFondation Brain CanadaSunovionMedical Research CouncilServierInstitut National Du CancerNational Alliance for Research on Schizophrenia and DepressionBristol-Myers SquibbCanadian Network for Mood and Anxiety TreatmentsFreistaat SachsenEli Lilly and CompanyAlzheimer's Disease Neuroimaging InitiativeNational Institutes of HealthChildren's Hospital FoundationSigne ja Ane Gyllenbergin SäätiöGlaxoSmithKlineConselho Nacional de Desenvolvimento Científico e TecnológicoBrain and Behavior Research FoundationOntario Brain InstituteUK Research and Innovation
KeywordsMajor depressive disorderNeurocognitivePsychologyDepression (economics)Working memoryLate life depressionCohortEffects of sleep deprivation on cognitive performanceCognitionClinical psychologyNeuropsychologyPsychiatryMedicineInternal medicine
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.102
Threshold uncertainty score0.727
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.037
GPT teacher head0.293
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations5
Published2024
Admission routes2
Has abstractno