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Record W4405044387 · doi:10.1016/s1473-3099(24)00667-4

Breadth of immune response, immunogenicity, reactogenicity, and safety for a pentavalent meningococcal ABCWY vaccine in healthy adolescents and young adults: results from a phase 3, randomised, controlled observer-blinded trial

2024· article· en· W4405044387 on OpenAlexaff
Terry Nolan, Chiranjiwi Bhusal, Jiřı́ Beran, Mark Bloch, Benhur Şirvan Çetin, Ener Çağrı Dinleyici, Daniel Dražan, Satu Kokko, Susanna Koski, Outi Laajalahti, Joanne M. Langley, Mika Rämet, Peter Richmond, Peter Silas, Bruce Tapiéro, Florence Tiong, Mary Tipton, Benita Ukkonen, Betül Ulukol, Maria Lattanzi, Mariano Di Trapani, Arnold Willemsen, Daniela Toneatto, Peter Richmond, Eugene Athan, Marije Dalebout, Ferdinandus de Looze, Tolga İ̇nce, Renata Adamovska, Martina Spaziererova, Josef Zemanek, Miroslav Pavlasek, Sandra Meisalu, Kaia Kiiroja, Ilkka Seppä, Pauliina Paavola, Marc Dionne, Anil K. Gupta, James D. Kellner, Noah Vale, Marie-Louise Vachon, Manish Sadarangani, Peter Dzongowski, Walter Rok, Martin Schear, William Simon, Jonathan Staben, Paul Grubb, Robert Jeanfreau, Enrique Pelayo, Minesh Patel, Rambod Rouhbakhsh, Daniel K. Finn, Joseph Surber, George Freeman, Maia Chakerian, Alexander Osowa, Kwabena Ayesu, Jake D. Jones, Ryan Gottfredson, John D. Scott, William Byars, Hemalini Mehta, Robert Carter, Rand Farjo, Ronald Ackerman, David Bernard, Isabelle Lechevin, Stéfanie Raulier, Dominique Wauters, Danielle Morelle

Bibliographic record

VenueThe Lancet Infectious Diseases · 2024
Typearticle
Languageen
FieldImmunology and Microbiology
TopicBacterial Infections and Vaccines
Canadian institutionsCentre Hospitalier Universitaire Sainte-JustineDalhousie University
FundersGlaxoSmithKline Biologicals
KeywordsReactogenicityMeningococcal vaccineMedicineImmunogenicityVaccinationMeningococcal diseaseRandomized controlled trialPediatricsNeisseria meningitidisImmune systemInternal medicineImmunologyImmunizationBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.077
Threshold uncertainty score0.869

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.024
GPT teacher head0.307
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations14
Published2024
Admission routes1
Has abstractno

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