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Record W4405049724 · doi:10.1016/s2468-1253(24)00311-x

International consensus statement on microbiome testing in clinical practice

2024· review· en· W4405049724 on OpenAlexaff
Serena Porcari, Benjamin H. Mullish, Francesco Asnicar, Siew C. Ng, Liping Zhao, Richard Hansen, Paul W. O’Toole, Jeroen Raes, Georgina L. Hold, Lorenza Putignani, Christian Lodberg Hvas, Georg Zeller, Omry Koren, Hein M. Tun, Mireia Valles‐Colomer, María Carmen Collado, Monika Fischer, Jessica R. Allegretti, Tariq Iqbal, Benoit Chassaing, Josbert J. Keller, Simon Mark Dahl Baunwall, María T. Abreu, Giovanni Barbara, Faming Zhang, Francesca Romana Ponziani, Samuel P. Costello, Sudarshan Paramsothy, Dina Kao, Colleen Kelly, Juozas Kupčinskas, Ilan Youngster, Francesco Franceschi, Sahil Khanna, Maria J. G. T. Vehreschild, Alexander Link, Flavio De Maio, Edoardo Pasolli, Aitor Blanco‐Míguez, Patrizia Brigidi, Brunella Posteraro, Franco Scaldaferri, Françis Mégraud, Peter Malfertheiner, Luca Masucci, Manimozhiyan Arumugam, Nadeem O. Kaakoush, Eran Segal, Jasmohan S. Bajaj, Rupert W. Leong, John F. Cryan, Rinse K. Weersma, Rob Knight, Francisco Guarner, Fergus Shanahan, Patrice D. Cani, Eran Elinav, Maurizio Sanguinetti, Willem M. de Vos, Emad El‐Omar, Joël Doré, Julian R. Marchesi, Herbert Tilg, Harry Sokol, Nicola Segata, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro

Bibliographic record

Venue˜The œLancet. Gastroenterology & hepatology · 2024
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGut microbiota and health
Canadian institutionsUniversity of Alberta
FundersMinistero dell'Istruzione e del MeritoH2020 European Research CouncilAgencia Estatal de InvestigaciónMedical Research CouncilHorizon 2020 Framework ProgrammeNational Institutes of HealthGrifolsNational Heart, Lung, and Blood InstituteFondazione RomaIpsenAboca S.p.A. Società AgricolaCelltrionEisaiAstellas PharmaEli Lilly and CompanyAssociazione Italiana per la Ricerca sul CancroGastroenterological Society of AustraliaChinese University of Hong KongJanssen PharmaceuticalsMinistero dell’Istruzione, dell’Università e della RicercaNovo NordiskDr. Falk PharmaNational Institute for Health and Care ResearchImperial College Healthcare NHS TrustImperial College LondonDanoneTillotts PharmaFonds De La Recherche Scientifique - FNRSEuropean Research CouncilMinisterio de Ciencia, Innovación y UniversidadesCelgeneNational Cancer InstituteHORIZON EUROPE Framework ProgrammeServierGilead SciencesAmgenNational Health and Medical Research CouncilWalloon excellence in life sciences and biotechnologySeres TherapeuticsSanofiMinistero della SalutePfizer
KeywordsMicrobiomeMultidisciplinary approachHuman microbiomeMedicineClinical PracticeHealth careRisk analysis (engineering)Engineering ethicsIntensive care medicineBioinformaticsEngineeringNursingPolitical scienceBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.033
metaresearch head score (Gemma)0.048
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.033
Threshold uncertainty score0.176

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0330.048
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0050.004
Bibliometrics0.0040.004
Science and technology studies0.0010.003
Scholarly communication0.0050.004
Open science0.0050.006
Research integrity0.0120.012
Insufficient payload (model declined to judge)0.0090.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.092
GPT teacher head0.424
Teacher spread0.332 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations73
Published2024
Admission routes1
Has abstractno

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Same venue˜The œLancet. Gastroenterology & hepatologySame topicGut microbiota and healthFrench-language works237,207