Mechanism study on the enhancement of bile acid-binding capacity in corn by-product juice via Lactiplantibacillus plantarum HY127 fermentation
Bibliographic record
Abstract
Hyperlipidemia is a common endocrine metabolic disease in humans. Long-term medications often have adverse effects, making the search for safer and more effective treatments crucial. This study aimed to explore the impacts and mechanisms of Lactiplantibacillus plantarum HY127 fermentation on enhancing bile acid-binding capacity (BABC). We fermented corn by-product juice (CBJ) by HY127 and investigated the BABC of HY127 bacterial cells and their metabolites. Our results indicated that HY127 cells (95.25 %) played a major role in enhancing BABC, with metabolites (31.50 %–66.41 %) also contributing. Compared to unfermented CBJ, the contents of phenolics, flavonoids, polysaccharides, and organic acids were significantly higher. Non-targeted metabolomics revealed upregulated amino acids, alkaloids, terpenoids, and other bioactive substances associated with BABC in the supernatant. This study confirmed that HY127 fermentation enhances the BABC of CBJ (increased by 32.02 %–78.76 %), providing a research foundation and technical reference for the development of LAB-fermented corn by-product beverages with hypolipidemic activities. • Lactiplantibacillus plantarum HY127 fermentation enhanced bile acid-binding capacity in corn by-product juice. • Metabolomics detected metabolites in corn by-product juice before/after fermentation. • Explored the mechanisms of fermentation on enhancing BABC.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".