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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Véronique Vitart, Stefan Weiß, Jeanette Erdmann, Kristian Hveem, Florian Kronenberg, Wen‐Jane Lee, Hilary C. Martin, QiPing Feng, Klaus Stark, Peter Kraft, Raymond Noordam, Franco Giulianini, Sailaja Vedantam, Peter J. van der Most, Patricia A. Peyser, Peter S. Braund, Patrik K. E. Magnusson, Giriraj R. Chandak, Lenore J. Launer, Bahram Namjou, Håkon Håkonarson, Heribert Schunkert, George Hindy, Jun Takayama, Martha L. Daviglus, Iris M. Heid, Shahid Abbas, Zi‐Bing Jin, Jonathan P. Bradfield, Liubov Arbeeva, Mauro Pala, Graciela E. Delgado, Mi Yeong Hwang, Vasiliki Mamakou, Masayuki Yamamoto, Gabriel Cuéllar-Partida, Sandra Freitag-Wolf, Laura Lorés‐Motta, Norihiro Kato, Brenda W.J.H. Penninx, Jacqueline de Graaf, Jessica D. Faul, Josep M. Mercader, Hampton L. Leonard, Pradeep Natarajan, David P. Strachan, Andrew R. Wood, Jennifer A. Pacheco, Cornelia M. van Duijn, Peter Sever, John B. Whitfield, Gert J. de Borst, Mike A. Nalls, Katherine A. Kentistou, Edith Hofer, Rajkumar Dorajoo, Martina E. Zimmermann, Julie E. Buring, Joachim Thiery, Carol A. Wang, Esteban J. Parra, Rodney J. Scott, Wolfgang Lieb, Sekar Kathiresan, Lambertus A. Kiemeney, Henrik Vestergaard, Neil R Poulter, Jonathan Marten, Kyong‐Mi Chang, Dorret I. Boomsma, Päivi Pajukanta, Laura J. Smyth, Eleanor M. Simonsick, Michael V. Holmes, Fumihiko Matsuda, Stefan Gustafsson, Ananyo Choudhury, Bernhard Banas, Huaixing Li, Maoxuan Lin, Matt J. Neville, Alex P. Reiner, Shufeng Chen, Michele K. Evans, Yvonne M. Golightly, Dan Mellström, Jonathan Judd, John C. Chambers, Xiaofeng Zhu, Azra Kurbasic, Sailalitha Bollepalli, Michael R. Brown, Zeyuan Wang, Suraj S. Nongmaithem, Matthias B. Schulze, Eco J. C. de Geus, Jing-Hua Zhao, Sohee Han, Nicholas J. Timpson, Mariaelisa Graff, Cristen J. Willer, Aris Baras, Hyung‐Lae Kim, Xiao-Ou Shu, Zishan Gao, Joline W. J. Beulens, Mitsuhiro Yokota, Chao A. Hsiung, Yukinori Okada, Zoltán Kutalik, Jennifer A. Brody, Christian Gieger, Ellen M. Schmidt, Austin T. Hilliard, Christopher Oldmeadow, Bettina Jung, M. Arfan Ikram, E. Shyong Tai, Dwaipayan Bharadwaj, Allan Linneberg, Nish Chaturvedi, Unnur Þorsteinsdóttir, Yoichiro Kamatani, Ko Willems van Dijk, Henry Christensen, Juan Carlos Fernández-López, Yun Ju Sung, Annette Peters, Cucca Francesco, Shweta Ramdas, Joyce B. J. van Meurs, Morgan O. Obura, Anita Pandit, Julia Ramírez, Tota Giardoglou, Adolfo Correa, Folkert W. Asselbergs, Lorraine Southam, Dermot F. Reilly, Reinhold Schmidt, Bong-Jo Kim, Marylyn D. Ritchie, Giorgia Girotto, Qin Hui, Jason E. Miller, Trevor A. Mori, Jingyun Yang, J. Wouter Jukema, Hugh Watkins, Xiaohui Li, Paul S. de Vries, Anne E. Justice, Paraskevi Christofidou, Eva Rabing Brix Petersen, Daníel F. Guðbjartsson, Chew‐Kiat Heng, Philip S. Tsao, Konain Fatima Bhatti, George Dedoussis, Marjo‐Riitta Järvelin, Amy Jayne McKnight, Imo E. Hoefer, Bertha Hidalgo, Daisuke D. Ikeda, Rebecca D. Jackson, Naveed Sattar, Michèle Ramsay, Johanna Kuusisto, Mette Aadahl, Y. Eugene Chen, Claes Ohlsson, Karina Meidtner, Ivana Kolčić, Kari Stefansson, Joseph M. Zmuda, Harold Snieder, Minna Männikkö, Sanni E. Ruotsalainen, Anubha Mahajan, Andrew P. Morris, Charles Kooperberg, Shaofeng Huo, Scott Hazelhurst, Jaakko Tuomilehto, Hyejin Lee, Xiang Zhu, Anne Ahrendt Bjerregaard, Ronald M. Krauss, Liming Li, Sahoko Ichihara, Gudmar Thorleifsson, Albertine J. Oldehinkel, Meena Kumari, Louis Përusse, Tien Yin Wong, Bruce M. Psaty, Anurag Verma, E. Warwick Daw, Jong‐Young Lee, Lars Lind, Carlos A. Aguilar‐Salinas, Kyungheon Yoon, Harri Niinikoski, Patricia B. Munroe, Sander W. van der Laan, Ruth E. Mitchell, Mark I. McCarthy, Anneke I. den Hollander, Joshua C. Bis, Thomas Meinertz Dantoft, Matthias Munz, Marcus E. Kleber, Tim D. Spector, Charumathi Sabanayagam, Gina M. Peloso, Mika Kivimäki, Maria Pina Concas, H. Janaka de Silva, Ivan Brandslund, Jouke‐Jan Hottenga, Saori Sakaue, Jost B. Jonas, Gauri Prasad, Ísleifur Ólafsson, Andrew Wong, Nicholas G. Martin, Markus Scholz, Struan F.A. Grant, Susanne Jäger, Andrew Wells, Ruth J. F. Loos, Jorgen Engmann, Themistocles L. Assimes, Penny Gordon‐Larsen, Leslie A. Lange, Nancy L. Pedersen, Kuan-Han H. Wu, Alessandra Chesi, Stefania Bandinelli, Bin Yang, Jaakko Kaprio, Tessel E. Galesloot, Peter K. Joshi, Caroline Hayward, Ani Manichaikul, Xiuqing Guo, Lukas Forer, Hye-Mi Jang, Han‐Na Kim, Hyeok Sun Choi, Lisa W. Martin, Anu Loukola, Todd Lingren, Line T. Møllehave, Eirini Marouli, Jifeng Zhang, Ayşe Demirkan, Humaira Rasheed, Timothy M. Frayling, Maria Nethander, Alaitz Poveda, Dominique P.V. de Kleijn, Million Veterans Program, Nilesh J. Samani, Xiangfeng Lu, Yogasudha Veturi, Valeriya Lyssenko, Erik Ingelsson, Hongyan Huang, Jennifer A. Smith, Seungho Ryu, Aaron F. McDaid, Adriaan O. Kraaijeveld, Jianfeng Huang, Michael A. Province, Constance Turman, Zhengming Chen, John Attia, Nigel W. Rayner, Maria Sabater‐Lleal, Karen L. Mohlke, Joel N. Hirschhorn, Ben M. Brumpton, Marguerite R. Irvin, Scott M. Damrauer, Carolina Medina‐Gómez, Prashantha Hebbar, Asif Rasheed, Katja Pahkala, Adam E. Locke, Mary F. Feitosa, L. Adrienne Cupples, Jean‐Claude Tardif, Wei Zhou, Charles N. Rotimi, Rui Xia, Christian Couture, Mark S. Walker, Shoa L. Clarke, Tomohiro Katsuya, Yoshinori Murakami, John Michael Gaziano, Aki S. Havulinna, Jianjun Liu, Greg J.M. Zajac, M. Geoffrey Hayes, Elisabeth Widén, Ιωάννα Ντάλλα, Kuang Lin, Massimo Mangino, Young Jin Kim, Jer-Yuarn Wu, Karen A. Hunt, Amanda E. Nelson, Christopher J. O’Donnell, Gerard Pasterkamp, Dennis O. Mook‐Kanamori, Jae Hun Shin, Yii-Der Ida Chen, Alicia Huerta‐Chagoya, Daniela Ruggiero, Georg Homuth, Dongfeng Gu, Amy R. Bentley, Guillaume Lettre, Michael Preuß, Yasuharu Tabara, Hieab H.H. Adams, Philip L. De Jager, Jian’an Luan, Dhriti Sengupta, Gail P. Jarvik, Ozren Polašek, Craig E. Pennell, Fangchao Liu, Heikki A. Koistinen, Paul W. Franks, Eleftheria Zeggini, Ananda R. Wickremasinghe, Pedro Marques‐Vidal, Michiaki Kubo, Peter P. Pramstaller, Daiane Hemerich, Paul R. H. J. Timmers, Ayo P. Doumatey, Chao Xue, Leen M. ‘t Hart, Eung Kweon Kim, Morris Brown, Olga Giannakopoulou, Mika Kähönen, Ching‐Yu Cheng, Miguel Cruz, Oluf Pedersen, Simon Haworth, Tsao L. Noah, Clicerio González Villalpando, Wei Zhao, Jeffrey Haessler, Niels Grarup, Mark J. Caulfield, Wei Zheng, Aliki‐Eleni Farmaki, Jin Fang Chai, Péter Kovács, Danish Saleheen, Stella Trompet, Jerome I. Rotter, Richard C. Trembath, Alex W. Hewitt, Anke Tönjes, Hengtong Li, Qiuyin Cai, Masahiro Nakatochi, Masato Akiyama, Marina Ciullo, Fan Lü, Anna Morgan, Nicholas J. Wareham, Veikko Salomaa, Daniel I. Chasman, Robin Walters, Matthias Wielscher, David A. van Heel, Jan Walter Benjamins, Claude Bouchard, Chiea Chuen Khor, Mohsen Ghanbari, Adebowale Adeyemo, James G. Wilson, Anna Helgadóttir, Teresa Tusié‐Luna, Yingji Ji, Wen Bin Wei, Lorena Orozco, Chaolong Wang, Olli T. Raitakari, Pekka Jousilahti, Paul M. Ridker, Lοukianos S. Rallidis, Blair H. Smith, Pim van der Harst, Panos Deloukas, Bhavi Trivedi, Henry Völzke, Christopher P. Nelson, Brian E. Cade, Aneta Aleksandra Nielsen, Helen R. Warren, Achilleas Pitsillides, Niek Verweij, Elisabeth A. Rosenthal, Andre Franke, Akira Narita, Sonny Augustin Bechayda, Wayne Huey‐Herng Sheu, Frank Kee, Marisa Cañadas‐Garre, Rob M. van Dam, Ya Xing Wang, Natalie Terzikhan, Teresa Nutile, Myriam Fornage, Corri Black, Nuno R. Zilhäo, Sang Youl Rhee, Niina Pitkänen, Toru Nabika, Alan B. Zonderman, Michael Boehnke, Jaspal S. Kooner, Markku Laakso, Harry Campbell, Claudia Langenberg, Yoon Shin Cho, Brandon M. Wenz, Jessica van Setten, Sophie C. Warner, Hua Tang, Terho Lehtimäki, Peter W.F. Wilson, Sebastian Schönherr, Fahd Al‐Mulla, Iona Y. Millwood, Jie Yao, Cassandra N. Spracklen, Yuxuan Wang, Börge Schmidt, Susan Redline, Elizabeth Theusch, Phuong Le, Jian‐Min Yuan, Karen He, Alanna C. Morrison, Masahiro Kanai, Petra J. M. Elders, Paul Mitchell, Roderick C. Slieker, Global Neurodegeneration Proteomics Consortium Global Neurod Consortium, Linda S. Adair, Goncalo Abecasis, Matteo Floris, Jun Liu, Lingyao Zeng, Sarah E. Graham, Carina Emmel, Ida Surakka, Fumihiko Takeuchi, Jeong‐Taek Woo, Anuj Goel, Winfried März, Yuk‐Lam Ho, Jette Bork‐Jensen, Haretsugu Hishigaki, Ken Sin Lo, Daniel J. Rader, Chikashi Terao, Jonathan S. Mitchell, Ketian Yu, Nina Hutri‐Kähönen, Jian Yang, Shih‐Yi Lin, Jirong Long, D.C. Rao, Helena Schmidt, Stavroula Kanoni, Archie Campbell, Derek Klarin, Tamiya, Carsten A. Böger, Kelly Cho, Takahisa Kawaguchi, Sarah H. Wild, Vilmundur Guðnason, Julie A. Lynch, Hilma Holm, Kaare Christensen, Xueling Sim, Fredrik Karpe, Donna K. Arnett, Leo-Pekka Lyytikäinen, Marc Pauper, Christian Fuchsberger, Thomas W. Winkler, Thangavel Alphonse Thanaraj, Jun‐Sing Wang, David A. Bennett, Hiroyuki Iha, Xianyong Yin, Kumaraswamy Naidu Chitrala, Karl‐Heinz Jöckel, Kari E. North, Laura J. Scott, Wei-Qi Wei, Lawrence F. Bielak, Bjørn Olav Åsvold, Christopher D. Brown, Ginevra Biino, Samuli Ripatti, Line Lund Kårhus, Yuki Bradford, Mary K. Wojczynski, Kjell Nikus, Alagu Sankareswaran, Simona Vaccargiu, Wei Huang
Bibliographic record
VenueUNC Libraries · 2024
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRNA and protein synthesis mechanisms
Canadian institutionsnot available
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesFogarty International CenterGreat Southern Development Commission, Government of Western AustraliaNational Human Genome Research InstituteHelmholtz Zentrum MünchenNational Key Research and Development Program of ChinaEuropean Regional Development FundCambridge Institute for Medical Research, University of CambridgeEconomic and Social Research CouncilSamsungNational Institutes of HealthKorea Research Environment Open NetworkAvera Institute for Human GeneticsNational Institute on AgingUniversität GreifswaldMRC-PHE Centre for Environment and HealthInstituto de Salud Carlos IIINational Institute for Nutrition and HealthNorwegian Biodiversity Information CentreChief Scientist Office, Scottish Government Health and Social Care DirectorateMinistry of Science and ICT, South KoreaInstitut de Cardiologie de MontréalImperial College LondonKing's College LondonFondation Institut de Cardiologie de MontréalTaichung Veterans General HospitalForsknings- og InnovationsstyrelsenMedical Research Council CanadaWetenschappelijk Onderzoek- en DocumentatiecentrumRadboud Universitair Medisch CentrumOffice of Research and DevelopmentSydäntutkimussäätiöLeids Universitair Medisch CentrumAstellas PharmaInstituto Mexicano del Seguro SocialNovo NordiskNational Institute for Health Research Health Protection Research UnitVetenskapsrådetKorea National Institute of HealthOesterreichische NationalbankMinistry of Education, Culture, Sports, Science and TechnologyGovernment of Western AustraliaKarolinska InstitutetMedical Research CouncilHjärt-LungfondenHelsefondenKorea Institute of Science and Technology InformationKorea Institute of Science and TechnologyAccareFinska LäkaresällskapetErasmus Medisch CentrumNational Medical Research CouncilKfH-Stiftung PräventivmedizinStockholms Läns LandstingNational Science CouncilNational Research Foundation of KoreaKoninklijke Nederlandse Akademie van WetenschappenNational Natural Science Foundation of ChinaFoundation for Cardiovascular ResearchZonMwNIH Office of the DirectorUniversity of Notre Dame AustraliaEdith Cowan UniversityStiftelsen för Strategisk ForskningCompute CanadaRadboud UniversiteitNational Heart, Lung, and Blood InstituteUniversiteit LeidenNederlandse Organisatie voor Wetenschappelijk OnderzoekChinese Academy of SciencesSundhed og Sygdom, Det Frie ForskningsrådMurdoch UniversityChina-Japan Friendship HospitalDeutsche ForschungsgemeinschaftFondation LeducqHallym UniversityAustrian Science FundNational Institute for Health and Care ResearchNational Research FoundationNational Center for Advancing Translational SciencesEuropean Science FoundationBundesministerium für Bildung und ForschungMinistero dell’Istruzione, dell’Università e della RicercaBritish Heart FoundationWomen and Infants Research FoundationCurtin University of TechnologyJapan Agency for Medical Research and DevelopmentRaine Medical Research FoundationDaiwa Securities Health FoundationUniversity of BristolCanadian Institutes of Health ResearchEuropean CommissionKnut och Alice Wallenbergs StiftelseNIHR Cambridge Biomedical Research CentreScottish Funding CouncilNovo Nordisk Foundation Center for Basic Metabolic ResearchUniversity of Notre DameHealth and Safety ExecutiveNational Health and Medical Research CouncilDeutsche KrebshilfeUniversity of OxfordAstraZenecaU.S. Department of Veterans AffairsRegion HovedstadenDepartment for the EconomyScottish GovernmentBroad InstituteAustralian GovernmentImperial College Healthcare NHS TrustPerelman School of Medicine, University of PennsylvaniaCancer Research UKWellcome TrustEU Joint Programme – Neurodegenerative Disease ResearchNational Institute of Child Health and Human DevelopmentJan Dekker StichtingHjerteforeningenHelsinki Institute of Life Science, Helsingin YliopistoJuvenile Diabetes Research Foundation InternationalNational Institute of Allergy and Infectious DiseasesDanish Agency for Science and Higher EducationGlaxoSmithKlineGenome CanadaGratama StichtingUniversität RegensburgSchool of Medicine, Boston UniversityHelsingin YliopistoPublic Health AgencyCenter of Innovation ProgramUniversity of PennsylvaniaU.S. Department of Health and Human ServicesAmerican Diabetes AssociationAmerican Heart AssociationScience Foundation IrelandNational Science FoundationAndrea and Charles Bronfman PhilanthropiesDiabetes UK
KeywordsVariation (astronomy)Layer (electronics)Computational biologyBiologyGeneticsEvolutionary biologyChemistry
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.030
GPT teacher head0.242
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
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Citations0
Published2024
Admission routes1
Has abstractno