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Record W4407683020 · doi:10.1021/acs.oprd.4c00422

Inverse Transformation of Glycine by Crystal Size Control

2025· article· en· W4407683020 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueOrganic Process Research & Development · 2025
Typearticle
Languageen
FieldMaterials Science
TopicCrystallization and Solubility Studies
Canadian institutionsProcess Research Ortech (Canada)
FundersNational Research Foundation of Korea
KeywordsGlycineTransformation (genetics)InverseCrystal (programming language)ChemistryMathematicsMaterials scienceComputer scienceAmino acidBiochemistry

Abstract

fetched live from OpenAlex

This study proposed a method for inverse phase transformation of stable γ-glycine into metastable α-glycine by using the characteristic that solubility increases as crystal size decreases according to the Ostwald–Freundlich equation. First, we measured the change in solubility according to the particle size of glycine. The solubility of γ-glycine bulk crystals at 10 °C in water was 173 g/L, and when the crystal size decreased to about 0.9 μm, the solubility increased to about 185 g/L. This concentration was higher than the solubility of α-glycine bulk crystals, 180 g/L. Based on the above results, γ-glycine can be inverse transformed into α-glycine in aqueous solution. To demonstrate this inverse transformation, in a glycine solution, γ-glycine crystals with a size of about 2 μm were ground with glass beads for 24 h to reduce the crystal size to about 0.8 μm. And the concentration of the solution was made higher than the solubility of α-glycine bulk. α-Glycine bulk crystals (about 110 μm) were placed into this solution and grown to 170 μm. Through this, inverse phase transformation was achieved in which γ-glycine crystals were dissolved and α-glycine crystals grew. The above inverse phase transformation process was confirmed using a microscope, XRD, and ATR–FTIR.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.023
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.329
Teacher spread0.309 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it