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Record W4409423955 · doi:10.1038/s41591-025-03635-5

CONSORT 2025 statement: updated guideline for reporting randomized trials

2025· review· en· W4409423955 on OpenAlexafffund
Sally Hopewell, An‐Wen Chan, Gary S. Collins, Asbjørn Hróbjartsson, David Moher, Kenneth F. Schulz, R. Tunn, Rakesh Aggarwal, Michael Berkwits, Jesse A. Berlin, Nita Bhandari, Nancy J. Butcher, Marion Campbell, Runcie C.W. Chidebe, Diana Elbourne, Andrew Farmer, Dean Fergusson, Robert Golub, Steven N. Goodman, Tammy Hoffmann, John P. A. Ioannidis, Brennan C Kahan, Rachel L Knowles, Sarah E Lamb, Steff Lewis, Elizabeth Loder, Martin Offringa, Philippe Ravaud, Dawn P. Richards, Frank W. Rockhold, David L. Schriger, Nandi Siegfried, Sophie Staniszewska, R. Taylor, Lehana Thabane, David Torgerson, Sunita Vohra, Ian R. White, Isabelle Boutron

Bibliographic record

VenueNature Medicine · 2025
Typereview
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsImpactUniversity of AlbertaRobarts Clinical TrialsUniversity of TorontoSickKids FoundationSt. Joseph’s Healthcare HamiltonHospital for Sick ChildrenOttawa HospitalMcMaster UniversityWomen's College Hospital
FundersDuke Clinical Research InstituteKlinisk Institut, Syddansk UniversitetWarwick Medical SchoolGreat Ormond Street Institute of Child HealthUniversity of North Carolina at Chapel HillOffice of ScienceCenters for Disease Control and PreventionUniversity of ExeterJawaharlal Institute Of Postgraduate Medical Education and ResearchSyddansk UniversitetUniversity of AberdeenInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementInstitut National de la Santé et de la Recherche MédicaleUniversity of TorontoUniversity of GlasgowUniversity of WarwickUniversity of OxfordUniversity College LondonUniversity of OttawaMedical Research CouncilDepartment of Health and Social CareNational Institute for Health and Care ResearchSouth African Medical Research CouncilUniversity of AlbertaUniversity of California, Los AngelesLondon School of Hygiene and Tropical MedicineOttawa Hospital Research InstituteMcMaster UniversityUniversity of MiamiNorthwestern UniversityOdense UniversitetshospitalSchool of Medicine, University of North Carolina at Chapel HillHospital for Sick ChildrenBond University
KeywordsConsolidated Standards of Reporting TrialsGuidelineStatement (logic)Randomized controlled trialMedicineMEDLINEFamily medicinePolitical scienceInternal medicinePathologyLaw

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.196
metaresearch head score (Gemma)0.504
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesMetaresearch
DomainCandidate signal: Reporting · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.804
Threshold uncertainty score0.991

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1960.504
Meta-epidemiology (narrow)0.0060.007
Meta-epidemiology (broad)0.0160.028
Bibliometrics0.0170.022
Science and technology studies0.0020.004
Scholarly communication0.0120.005
Open science0.0070.007
Research integrity0.0130.019
Insufficient payload (model declined to judge)0.0370.025

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.865
GPT teacher head0.699
Teacher spread0.166 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.

Study designNot applicable
DomainReporting
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations197
Published2025
Admission routes2
Has abstractno

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