Validity & Reliability of Using Musculoskeletal Ultrasound to Measure Cervical Disc Height
Bibliographic record
Abstract
Background: Cervical intervertebral disc (IVD) height can be used to indirectly measure of IVD hydration status. Intervertebral disc dehydration results in height loss, which can contribute to degenerative disc disease. There is need for in situ cervical IVD ultrasound assessment to better understand spinal health. Purpose: To determine reliability and validity of musculoskeletal ultrasound (MSU) as a tool to measure cervical IVD height compared to magnetic resonance imaging (MRI) at C4-5, C5-6 and C6-7 spinal segments. Study Design: Exploratory Cross-Sectional Study. Methods: This three-phase study enrolled 40 participants. Over the course of the study, 900 measurements of IVD were taken. Ten subjects participated in cervical spine MRI and MSU imaging to determine inter-rater reliability for cervical IVD height measurements. Twenty subjects underwent MRI and MSU to obtain images for measurement comparison and Bland-Altman Analysis assessed agreement between MSU and MRI (α=.05) for validity. Randomized, blinded, repeated-measures design using mean values was used to determine inter-rater reliability with intraclass correlation coefficient (ICC(2,3)) and standard error of measurement (SEM) at each IVD segment. Results: Anterior cervical IVD height of MRI and MSU were ≥0.91(95%CI=0.66-0.98) and ≥0.68(95%CI=0.27-0.92), respectively. Musculoskeletal ultrasound measurement's SEM between raters was comparable to MRI at ≤0.43mm (7.9%). No significant differences nor proportional bias between MRI and MSU measurements (p<0.05) were found at any IVD spinal level, r(18)=0.83, p<0.01. Average underestimation of MSU measurements compared to MRI was ≤ -0.10mm (2.2%). Conclusion: Methodology used for MSU cervical IVD height imaging and measurements was found to be moderately to highly reliable. Comparisons measurements between MRI and MSU support the use of MSU to measure cervical IVD height in future investigations, including variables which may affect the IVD hydration and homeostasis. Level of evidence: I 3.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".