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Record W4412956200 · doi:10.1186/s12961-025-01374-0

How does integrated knowledge translation work? A realist review

2025· review· en· W4412956200 on OpenAlexafffund
Anita Kothari, Shannon L. Sibbald, Chris McCutcheon, Whitney Berta, Robin Urquhart, Tanya Horsley, Leigha Comer, Ian D. Graham

Bibliographic record

VenueHealth Research Policy and Systems · 2025
Typereview
Languageen
FieldHealth Professions
TopicHealth Policy Implementation Science
Canadian institutionsUniversity of OttawaRoyal College of Physicians and Surgeons of CanadaUniversity of TorontoDalhousie UniversityOttawa HospitalLondon Health Sciences CentreWestern University
FundersCanadian Institutes of Health Research
KeywordsHealth services researchHealth administrationKnowledge translationPublic healthWork (physics)Health informaticsMedicineTranslation (biology)Knowledge managementNursingComputer scienceEngineering

Abstract

fetched live from OpenAlex

BACKGROUND: Integrated knowledge translation (IKT), or research co-production, is a research approach where researchers and knowledge users carry out a study as equal partners. A growing evidence base demonstrates that IKT produces research findings that are useful, usable and used. Despite knowing how IKT works, we have yet to ascertain how it operates. We conducted a realist review to examine the key mechanisms thought to explain how IKT approaches work in relation to the generation of research in the healthcare sector. METHODS: The research question was the following: what are the necessary conditions (context) and key mechanisms that explain the success of IKT in the healthcare sector? We conducted the review in two phases. During phase 1, we collaborated with knowledge users and scoped the literature to develop preliminary program theories. In phase 2, we inductively tested the preliminary program theories against the literature. We searched OVID Medline, Embase, PsycINFO, the Cumulative Index of Nursing and Allied Health Literature, Social Sciences Abstracts, and ABI Inform for empirical articles published between 2002 and 2017. An updated search included Embase and OVID Medline articles published between 2017 and 2020. The review includes 84 papers. We included articles written in English that focused on the health sector; encompassed the co-generation of research with researchers, policy-makers, administrators and/or practitioners; and evaluated the IKT approach. In analysing the retained articles, we produced three program theories by looking for common patterns and challenging and refining these theories. RESULTS: We postulate three program theories about how teams of researchers and knowledge users work to generate research. We identified three important conditions: infrastructure, role clarity and power sharing. Under particular infrastructure arrangements, effective partnerships are mechanisms that lead to the production of research findings relevant to knowledge users. Role clarity also triggers effective partnerships. With power sharing, synergy is a mechanism that leads to the use of findings. CONCLUSIONS: We identified different conditions (contextual factors), including infrastructure, role clarity and power sharing, in which IKT produces research findings that are of relevance to knowledge users and used in health settings. Effective partnerships are necessary but an insufficient mechanism for actual use of research findings, and must occur before the mechanism of partnership synergy. This work contributes to our understanding of how to enhance the uptake of evidence by presenting three program theories and a consolidated, mid-range theory of IKT.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmaMetaresearch
Domain: Methods · Genre: Review
About the Canadian research system: no · About a Canadian topic: no
Qualitativelow
gptMetaresearch
Domain: Methods · Genre: Review
About the Canadian research system: no · About a Canadian topic: no
Systematic reviewmedium
models splitAgreement compares identical category sets and study designs across arms.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.049
metaresearch head score (Gemma)0.027
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Science and technology studies, Research integrity
Consensus categoriesMetaresearch
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.547
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0490.027
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.000
Bibliometrics0.0030.008
Science and technology studies0.0030.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.004
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.955
GPT teacher head0.797
Teacher spread0.159 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Labeled directly by 2 models reading the full record.

Metaresearch

The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.

Study designQualitative · Systematic review
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractyes

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