Azetukalner, a Novel, Potent KV7 Potassium Channel Opener in Development for the Treatment of Focal Onset Seizures, Primary Generalized Tonic-Clonic Seizures, and Major Depressive Disorder
Bibliographic record
Abstract
Azetukalner is a novel, potent KV7 potassium channel opener with phase 3 trials ongoing for focal onset seizures (FOS), primary generalized tonic-clonic seizures, and planned for major depressive disorder (MDD). In the X-TOLE, phase 2b study in 325 adults with ≥4 focal seizures per month on 1–3 antiseizure medications (ASMs), azetukalner (10, 20, and 25 mg once-daily [QD] with food and no titration period) demonstrated dose-dependent reduction in FOS frequency: 33.2% (10 mg, P=0.04), 46.4% (20 mg, P<0.001), and 52.8% (25 mg, P<0.001) compared to 18.2% for placebo, and early onset of efficacy occurring within 1 week (10 mg P<0.05; 20 mg P<0.05; 25 mg P<0.001 vs placebo).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".