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Record W4413988624 · doi:10.1021/acsnano.5c12854

33 Unresolved Questions in Nanoscience and Nanotechnology

2025· article· en· W4413988624 on OpenAlexafffund
Chad A. Mirkin, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydın, Austin Biaggne, C. Jeffrey Brinker, Katherine E. Bujold, Y. Charles Cao, Rachel R. Chan, Chaojian Chen, Pengcheng Chen, Xiaodong Chen, Olivier J. G. L. Chevalier, Richard M. Crooks, Vinayak P. Dravid, Jingshan S. Du, Sasha B. Ebrahimi, Hongyou Fan, Omar K. Farha, C. Adrian Figg, Tanner D. Fink, Connor M. Forsyth, Harald Fuchs, Franz M. Geiger, Nathan C. Gianneschi, Kyle J. Gibson, David S. Ginger, Sishi Guo, Justin Hanes, Liang Hao, Jin Huang, Bryan M. Hunter, Fengwei Huo, Jeongmin Hwang, Rongchao Jin, Shana O. Kelley, Thomas J. Kempa, Youngeun Kim, Sergej Kudruk, Sneha Kumari, Kaitlin M. Landy, Ki‐Bum Lee, Noel J. Leon, Jun Li, Yuanwei Li, Zhiwei Li, Bin Liu, Guoliang Liu, Xiaogang Liu, Luis M. Liz‐Marzán, Jochen H. Lorch, Taokun Luo, Robert J. Macfarlane, Jill E. Millstone, Milan Mrksich, Catherine J. Murphy, Rajesh R. Naik, André E. Nel, Christopher Oetheimer, Jenny Orbeck, So‐Jung Park, Benjamin E. Partridge, Nicholas A. Peppas, Michelle L. Personick, Arindam Raj, Namrata Ramani, Michael B. Ross, Susan E. Ross, Edward H. Sargent, Tanushri Sengupta, George C. Schatz, Dwight S. Seferos, Tamar Seideman, Soyoung E. Seo, Bo Shen, Wooyoung Shim, Donghoon Shin, Ulrich Simon, Andrew J. Sinegra, Peter T. Smith, Alexander M. Spokoyny, Peter J. Stang, Alexander H. Stegh, J. Fraser Stoddart, Dayne F. Swearer, Weihong Tan, Michelle H. Teplensky, C. Shad Thaxton, David R. Walt, Mary Wang, Zhe Wang, Wei David Wei, Paul S. Weiss, Peter H. Winegar, Younan Xia, Yi Xie, Xiaoyang Xu, Peidong Yang, Yiming Yang, Zihao Ye, Kuk Ro Yoon, Cuizheng Zhang, Hua Zhang, Ke Zhang, Liangfang Zhang, Xiaoyu Zhang, Ye Zhang, Zijian Zheng, Wenjie Zhou, Shengshuang Zhu, Wei Zhu

Bibliographic record

VenueACS Nano · 2025
Typearticle
Languageen
FieldMaterials Science
TopicElectronic and Structural Properties of Oxides
Canadian institutionsUniversity of TorontoMcMaster University
FundersNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of General Medical SciencesNational Cancer InstituteNational Heart, Lung, and Blood InstituteEuropean Research CouncilNatural Sciences and Engineering Research Council of CanadaArmy Research OfficeNational Institute of Biomedical Imaging and BioengineeringUniversity of California, Los AngelesU.S. ArmyNational Institutes of HealthU.S. Department of EnergyNational Natural Science Foundation of ChinaState Key Laboratory of Chemo/Biosensing and ChemometricsHunan UniversityCanada First Research Excellence FundNational Research Foundation of KoreaU.S. Air ForceDeutsche ForschungsgemeinschaftSeoul National UniversityUniversity of TorontoNational Research FoundationNational Nuclear Security AdministrationGustavus and Louise Pfeiffer Research FoundationLefkofsky Family FoundationBoston UniversityCongressionally Directed Medical Research ProgramsChinese Academy of SciencesUniversity of MarylandAir Force Office of Scientific ResearchChan Zuckerberg InitiativeHartwell FoundationNew Jersey Commission on Spinal Cord ResearchNational Science FoundationToyota Research InstituteArnold and Mabel Beckman FoundationW. M. Keck FoundationAlzheimer's Association
KeywordsNanotechnologyApplications of nanotechnologyMaterials science

Abstract

fetched live from OpenAlex

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this Nano Focus, we pose and explore 33 questions whose answers could profoundly impact fields such as energy, electronics, the environment, optics, and medicine. These questions highlight the need for deeper foundational understanding, improved tools and techniques, and innovative applications─each with significant societal relevance. Together, they represent a global call-to-action for the scientific community.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.015
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.015
Threshold uncertainty score0.077

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0150.018
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.002
Science and technology studies0.0050.025
Scholarly communication0.0080.023
Open science0.0030.007
Research integrity0.0100.014
Insufficient payload (model declined to judge)0.0080.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.241
Teacher spread0.234 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2025
Admission routes2
Has abstractyes

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