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Record W4413988624 · doi:10.1021/acsnano.5c12854

33 Unresolved Questions in Nanoscience and Nanotechnology

2025· article· en· W4413988624 on OpenAlexafffund
Chad A. Mirkin, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydın, Austin Biaggne, C. Jeffrey Brinker, Katherine E. Bujold, Y. Charles Cao, Rachel R. Chan, Chaojian Chen, Pengcheng Chen, Xiaodong Chen, Olivier J. G. L. Chevalier, Richard M. Crooks, Vinayak P. Dravid, Jingshan S. Du, Sasha B. Ebrahimi, Hongyou Fan, Omar K. Farha, C. Adrian Figg, Tanner D. Fink, Connor M. Forsyth, Harald Fuchs, Franz M. Geiger, Nathan C. Gianneschi, Kyle J. Gibson, David S. Ginger, Sishi Guo, Justin Hanes, Liang Hao, Jin Huang, Bryan M. Hunter, Fengwei Huo, Jeongmin Hwang, Rongchao Jin, Shana O. Kelley, Thomas J. Kempa, Youngeun Kim, Sergej Kudruk, Sneha Kumari, Kaitlin M. Landy, Ki‐Bum Lee, Noel J. Leon, Jun Li, Yuanwei Li, Zhiwei Li, Bin Liu, Guoliang Liu, Xiaogang Liu, Luis M. Liz‐Marzán, Jochen H. Lorch, Taokun Luo, Robert J. Macfarlane, Jill E. Millstone, Milan Mrksich, Catherine J. Murphy, Rajesh R. Naik, André E. Nel, Christopher Oetheimer, Jenny Orbeck, So‐Jung Park, Benjamin E. Partridge, Nicholas A. Peppas, Michelle L. Personick, Arindam Raj, Namrata Ramani, Michael B. Ross, Susan E. Ross, Edward H. Sargent, Tanushri Sengupta, George C. Schatz, Dwight S. Seferos, Tamar Seideman, Soyoung E. Seo, Bo Shen, Wooyoung Shim, Donghoon Shin, Ulrich Simon, Andrew J. Sinegra, Peter T. Smith, Alexander M. Spokoyny, Peter J. Stang, Alexander H. Stegh, J. Fraser Stoddart, Dayne F. Swearer, Weihong Tan, Michelle H. Teplensky, C. Shad Thaxton, David R. Walt, Mary Wang, Zhe Wang, Wei David Wei, Paul S. Weiss, Peter H. Winegar, Younan Xia, Yi Xie, Xiaoyang Xu, Peidong Yang, Yiming Yang, Zihao Ye, Kuk Ro Yoon, Cuizheng Zhang, Hua Zhang, Ke Zhang, Liangfang Zhang, Xiaoyu Zhang, Ye Zhang, Zijian Zheng, Wenjie Zhou, Shengshuang Zhu, Wei Zhu

Bibliographic record

VenueACS Nano · 2025
Typearticle
Languageen
FieldMaterials Science
TopicElectronic and Structural Properties of Oxides
Canadian institutionsUniversity of TorontoMcMaster University
FundersNational Institute of Neurological Disorders and StrokeNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of General Medical SciencesNational Cancer InstituteNational Heart, Lung, and Blood InstituteEuropean Research CouncilNatural Sciences and Engineering Research Council of CanadaArmy Research OfficeNational Institute of Biomedical Imaging and BioengineeringUniversity of California, Los AngelesU.S. ArmyNational Institutes of HealthU.S. Department of EnergyNational Natural Science Foundation of ChinaState Key Laboratory of Chemo/Biosensing and ChemometricsHunan UniversityCanada First Research Excellence FundNational Research Foundation of KoreaU.S. Air ForceDeutsche ForschungsgemeinschaftSeoul National UniversityUniversity of TorontoNational Research FoundationNational Nuclear Security AdministrationGustavus and Louise Pfeiffer Research FoundationLefkofsky Family FoundationBoston UniversityCongressionally Directed Medical Research ProgramsChinese Academy of SciencesUniversity of MarylandAir Force Office of Scientific ResearchChan Zuckerberg InitiativeHartwell FoundationNew Jersey Commission on Spinal Cord ResearchNational Science FoundationToyota Research InstituteArnold and Mabel Beckman FoundationW. M. Keck FoundationAlzheimer's Association
KeywordsNanotechnologyApplications of nanotechnologyMaterials science

Abstract

fetched live from OpenAlex

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this Nano Focus, we pose and explore 33 questions whose answers could profoundly impact fields such as energy, electronics, the environment, optics, and medicine. These questions highlight the need for deeper foundational understanding, improved tools and techniques, and innovative applications─each with significant societal relevance. Together, they represent a global call-to-action for the scientific community.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.245

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.241
Teacher spread0.234 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2025
Admission routes2
Has abstractyes

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