Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
An integrated approach combining biological and chemical investigations were carried out to uncover novel cytotoxic molecules from diverse Papuan marine organisms. Of 386 marine-derived extracts, about 13% (50 extracts) showed significant toxicity in the Artemia salina lethality assay (LC50 ≤ 5 µg/mL). Analysis of the Z-factor and Z’-factor confirmed the excellent quality of the assay (Z = 0.76, Z’ = 0.5). Of the 50 active extracts, seven extracts from Achantostrongylophora ingens, Theonella sp., Ianthella basta, a cyanobacterium, a sponge from family Thorectidae, and a rare Axinella sp. were further evaluated for cytotoxicity against HEK293T, 1H NMR spectral, LC-HR-MS/MS, feature-based molecular networking (FBMN), and chemoinformatics analyses. The chemical analyses revealed the presence of 43 known and 381 putatively new bioactive molecules. The integrated biological and chemistry approach adopted in this study is effective for prioritising important marine extracts with high probability of discovering novel cytotoxic compounds.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it