Transcriptional cofactor AtSDR4L and its paralog DIG2 repress somatic embryogenesis during post-embryonic development in Arabidopsis
Bibliographic record
Abstract
Abstract Somatic embryogenesis, a developmental process advantageous as an alternative means for plant propagation due to the lack of maternal tissues and the ease of in vivo to in vitro knowledge transfer of embryogenesis, has been applied in studies on the regulatory mechanisms governing the developmental plasticity in plants. Core and accessory components of the polycomb repressive complexes (PRCs), the epigenetic regulatory machinery, are known to repress the transcription of genes that positively regulate the somatic embryogenesis in seedlings. Recent studies revealed that Arabidopsis thaliana SEED DORMANCY 4-LIKE (AtSDR4L), an interactor of a PRC accessory, represses the embryo developmental program for a successful switch from seed to seedling. However, little is known about the regulation of cell differentiation by AtSDR4L in seedlings. Here, we show that AtSDR4L, its paralog Dynamic Influencer of Gene expression 2 (DIG2), and PRC components share similar transcriptional regulatory dynamics, particularly on somatic embryogenesis-related genes. We further demonstrate that mutations in AtSDR4L and DIG2 lead to the formation of somatic embryo-like structures and a delay in cellular differentiation. Thus, transcriptional changes reflected by morphological defects associated with somatic embryogenesis in Atsdr4l dig2 mutants suggest that AtSDR4L and DIG2 prevent the dedifferentiation of cells for proper seedling growth through the transcriptional control of cell identity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".