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Record W4416582237 · doi:10.1371/journal.pone.0336045

Aging and episodic memory specificity: Evidence challenging a domain-general pattern separation decline

2025· article· en· W4416582237 on OpenAlexafffund
Ariana Youm, Mélanie Cohn, Katherine Duncan

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldNeuroscience
TopicMemory Processes and Influences
Canadian institutionsOntario Brain InstituteUniversity of TorontoUniversity Health Network
FundersNatural Sciences and Engineering Research Council of CanadaGeneral Motors of CanadaCanada Excellence Research Chairs, Government of CanadaCanada Foundation for InnovationCanadian Institutes of Health ResearchGovernment of Ontario
KeywordsEpisodic memoryMnemonicSemantic memoryPerceptionTask (project management)CognitionWorking memoryMemory errorsYoung adult

Abstract

fetched live from OpenAlex

Aging is associated with a decline in episodic memory specificity. This phenomenon has been observed across various memory tasks, such as the Mnemonic Similarity Task (MST), where older adults show a heightened tendency to falsely recognize perceptually similar items. While many studies suggest this impairment reflects a generalized reduction in pattern separation, others indicate that older adults may exhibit preserved discrimination abilities for semantic representations. Furthermore, pattern separation accounts also posit that a bias toward pattern completion, a process whereby partial cues reactivate whole representations, occurs with aging. However, the evidence for this shift remains mixed, which may be in part due to how pattern completion is commonly measured. The current study aimed to investigate whether aging affects memory discrimination for semantically similar content, using tasks that minimize reliance on visual-spatial processing and executive functioning, both of which tend to decline with age. We designed two independent tasks that respectively tax memory specificity and pattern completion: the Verbal Discrimination Task (VDT) and the Verbal Completion Task (VCT). Sixty-six younger adults and 66 older adults completed these tasks, and a subset also completed the Object MST (younger n = 33 and older n = 35) to allow for a direct comparison between visual and semantic similarity. Our results showed that, compared to younger adults, older adults exhibited greater deficits in memory specificity for perceptually similar lures (Object MST) than for semantically similar content (VDT), suggesting that age-related memory impairments may be more pronounced in perceptual domains. Additionally, older adults showed reduced performance on the VCT, suggesting that deficits in memory specificity may be independent of deficits in pattern completion. Together, these findings go against the view that age-related differences in memory specificity are strictly rooted in a modality-general pattern separation deficit.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.517

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.108
GPT teacher head0.316
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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