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Record W6890027164 · doi:10.3205/25ebm077

Research integrity assessment of randomized controlled trials in COVID-19 evidence syntheses: focus on ethics and trial registration

2025· article· en· W6890027164 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueGerman Medical Science (German Research Foundation) · 2025
Typearticle
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsCochrane
Fundersnot available
KeywordsRandomized controlled trialResearch ethicsFocus (optics)Clinical trialResearch designTrial registrationMEDLINEEthics committee

Abstract

fetched live from OpenAlex

Background/research question: Randomized controlled trials (RCTs) that follow the principles of research integrity (RI) are essential for production of reliable evidence synthesis. Key RI aspects include prospective trial registration and adherence to ethical standards. International guidelines [for full text, please go to the a.m. URL]

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmaMetaresearchResearch integrity
Domain: Methods · Genre: Empirical
About the Canadian research system: no · About a Canadian topic: no
Systematic reviewlow
gptMetaresearchMeta-epidemiology (broad)Research integrity
Domain: Methods · Genre: Review
About the Canadian research system: no · About a Canadian topic: no
Systematic reviewlow
models splitAgreement compares identical category sets and study designs across arms.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.968
metaresearch head score (Gemma)0.986
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Science and technology studies, Scholarly communication, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch, Science and technology studies
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.510
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.9680.986
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0100.002
Bibliometrics0.0060.011
Science and technology studies0.0020.008
Scholarly communication0.0040.001
Open science0.0050.001
Research integrity0.0000.004
Insufficient payload (model declined to judge)0.0090.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.894
GPT teacher head0.736
Teacher spread0.158 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it