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Record W6890027164 · doi:10.3205/25ebm077

Research integrity assessment of randomized controlled trials in COVID-19 evidence syntheses: focus on ethics and trial registration

2025· article· en· W6890027164 on OpenAlexaff

Bibliographic record

VenueGerman Medical Science (German Research Foundation) · 2025
Typearticle
Languageen
FieldDecision Sciences
TopicMeta-analysis and systematic reviews
Canadian institutionsCochrane
Fundersnot available
KeywordsRandomized controlled trialResearch ethicsFocus (optics)Clinical trialResearch designTrial registrationMEDLINEEthics committee

Abstract

fetched live from OpenAlex

Background/research question: Randomized controlled trials (RCTs) that follow the principles of research integrity (RI) are essential for production of reliable evidence synthesis. Key RI aspects include prospective trial registration and adherence to ethical standards. International guidelines [for full text, please go to the a.m. URL]

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmaMetaresearchResearch integrity
Domain: Methods · Genre: Empirical
About the Canadian research system: no · About a Canadian topic: no
Systematic reviewlow
gptMetaresearchMeta-epidemiology (broad)Research integrity
Domain: Methods · Genre: Review
About the Canadian research system: no · About a Canadian topic: no
Systematic reviewlow
models splitAgreement compares identical category sets and study designs across arms.

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.774
metaresearch head score (Gemma)0.914
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesMetaresearch
DomainCandidate signal: Methods · Consensus signal: Methods
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.981
Threshold uncertainty score0.279

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.7740.914
Meta-epidemiology (narrow)0.0040.007
Meta-epidemiology (broad)0.0170.013
Bibliometrics0.0250.031
Science and technology studies0.0070.023
Scholarly communication0.0240.017
Open science0.0110.015
Research integrity0.0190.018
Insufficient payload (model declined to judge)0.0490.024

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.894
GPT teacher head0.736
Teacher spread0.158 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Labeled directly by 2 models reading the full record.

MetaresearchResearch integrityMeta-epidemiology (broad)

The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.

Study designSystematic review
DomainMethods
GenreEmpirical · Review

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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