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Record W6998989435

Bioassays of Analogs of Pleurocidin-Amide Indicate that Change at <em>N</em>-Terminus is Key to Improved Efficacy

2011· article· en· W6998989435 on OpenAlexfundno aff

Bibliographic record

VenueJournal of Media Literacy Education · 2011
Typearticle
Languageen
FieldPharmacology, Toxicology and Pharmaceutics
TopicChemical Reactions and Isotopes
Canadian institutionsnot available
FundersNational Institute of Biomedical Imaging and BioengineeringNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Allergy and Infectious DiseasesNational Cancer InstituteNational Institute on Drug AbuseOffice of Naval ResearchAgencia Española de Cooperación Internacional para el DesarrolloFundação para a Ciência e a TecnologiaJapan Society for the Promotion of ScienceNational Health and Medical Research CouncilBasic Energy SciencesCanadian Institutes of Health ResearchUniversity of North Carolina at Chapel HillU.S. Public Health ServiceAmerican Chemical Society Petroleum Research FundOffice of ScienceUniversité de Reims Champagne-ArdenneDeutsche KrebshilfeIndian Institute of Technology BombayCentre National de la Recherche ScientifiqueNational Center of Neurology and PsychiatryAkademie Věd České RepublikyNational Center for Research ResourcesFonds Québécois de la Recherche sur la Nature et les TechnologiesCouncil for Higher EducationConselho Nacional de Desenvolvimento Científico e TecnológicoVINNOVAMinisterstvo Školství, Mládeže a TělovýchovyHeart and Stroke Foundation of CanadaCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorEuropean CommissionFundação de Amparo à Pesquisa do Estado de São PauloFP7 International CooperationNatural Sciences and Engineering Research Council of CanadaChina Scholarship CouncilMinistry of Education, Culture, Sports, Science and TechnologyDeutsche ForschungsgemeinschaftCamille and Henry Dreyfus FoundationAmerican Diabetes AssociationEnterprise IrelandAgencia Nacional de Promoción Científica y TecnológicaU.S. Department of DefenseCancer Research UKGrantová Agentura České RepublikyUniversità degli Studi di PadovaCystic Fibrosis CanadaInstitute for Research in BiomedicineUniversité LavalSanta Clara UniversityUniversitetet i TromsøGeneralitat de CatalunyaUniversidade Federal do ABCDepartment of Science and Technology, Ministry of Science and Technology, IndiaNational Institutes of HealthFlorida Department of HealthNational Science FoundationScience Foundation IrelandMinistero dell’Istruzione, dell’Università e della RicercaMedical Research CouncilProstate Cancer FoundationEli Lilly and CompanyResearch Corporation for Science AdvancementNational Institute of Dental and Craniofacial ResearchRoyal SocietyFonds National de la Recherche LuxembourgAmerican Heart AssociationUniversidad de Buenos AiresMinisterio de Ciencia e InnovaciónU.S. Department of Energy
KeywordsKey (lock)BioassayComponent (thermodynamics)Action (physics)
DOInot available

Abstract

fetched live from OpenAlex

American Peptide Society used the same production team (scientific and technical editor) as in 2009.And again, manuscripts were accepted through the internet page, entered into the database which allowed creating indexes on the fly and simplified communication with authors.Processed manuscripts were available for proofing -helping us to correct blunders made by us and authors in the rush to deliver the book as soon as possible.The finalized book was available on the website for downloading 8 weeks after the symposium ended.The "real book" is available from "just in time" printing process at www.lulu.com.Due to the fact that the American Peptide Society is a nonprofit organization, there is no margin charged for the book, and all members can order it for production cost.Our thanks go to all authors who delivered manuscripts of a high technical quality before the deadline.This time we had minimal number of authors trying to "squeeze in" three pages of text on two pages of manuscript, or modifying the template of the text file.Time to time we were amused by scientists leaving the parts of the original template text in their manuscripts, but in general, we received papers of reasonable quality.Due to the time constraints, we were not able to redo the graphical components of the manuscripts -graphs and illustrations -authors have to understand that some of the graphs looking good at the poster size are far from ideal for book page size.We believe that the quality of the figures and schemes is a part of the presentation skills of the authors and we let them show it.In the past we were insisting on the delivery of only monochromatic graphics with large enough details (fonts).However, since only less than 5% of

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.159
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.118
GPT teacher head0.395
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2011
Admission routes1
Has abstractyes

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