Is IL-23 the Winner? Lessons from Inflammatory Bowel Disease (IBD) and Psoriasis (PsO)
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Key Takeaways • Interleukin-23 (IL-23), and the IL-23/Th-17 interaction, plays a pivotal role in the pathogenesis of immune‑mediated diseases, such as psoriasis (PsO) and inflammatory bowel disease (IBD). This has led to the development and commercialization of several anti-IL-23 therapies, all demonstrating high efficacy and safety in the management of these conditions. • Anti-IL-23 therapies, have been shown to be amongst the most highly effective treatments in PsO, achieving meaningful and durable treatment response (PASI-90) in over 80 per cent of participants in registrational clinical trials, while in IBD the meaningful one-year efficacy, based on the varied definitions of the studies’ primary endpoints, is achieved (at most) in just over 50 per cent of participants, though rates of achieving remission in Crohn’s disease are much lower. • Several ongoing studies examining the role of IL-23 inhibition in specific IBD populations (ex. perianal Crohn’s disease), and studies examining the combination of IL-23 inhibitors with other targeted therapies, capitalizes on the excellent safety and efficacy profile of anti-IL-23, reflecting the long-term importance of these therapies in the IBD treatment landscape.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it