Response Mechanism of Lactobacillus plantarum under Simulated Digestion Based on Proteomics and Metabolomics Analysis
Bibliographic record
Abstract
Abstract Proteomics and a metabolomics strategy were used to investigate the probiotic properties of Lactobacillus plantarum BW2013 under simulated in vitro digestion. Thirty seven significant differential proteins including 6-phosphogluconate dehydrogenase, pyruvate kinase, F0F1 ATP synthase, ABC-type transporters, ribosomal and universal stress proteins and 40 significant differential metabolites, such as indole-3-lactic acid, Pro, trans-cinnamic acid, betaine, citric acid, D-fructose, and γ-aminobutyric acid were identified and characterized. The association analysis indicated that most upregulated proteins and metabolites are involved primarily in stress response, regulation of intestinal flora and accumulation of beneficial substances relating to carbohydrate and energy metabolic pathways, amino acid metabolism pathways, nucleotide metabolism pathways, overall/universal stress response. The results provide new insights into the response mechanism of L. plantarum BW2013 under the simulated digestion conditions, facilitating the exploitation of its potential application in probiotic products.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".