Record W7117112965 · doi:10.1016/j.eururo.2025.09.4174

RESECT: A Randomised Controlled Trial of Audit and Feedback in Non–muscle-invasive Bladder Cancer Surgery

2025· article· en· W7117112965 on OpenAlexaff

Kevin Gallagher, Steven MacLennan, Nikita Bhatt, Keiran Clement, Eleanor Zimmermann, Sinan Khadhouri, Meghana Kulkarni, Thineskrishna Anbarasan, Aqua Asif, Alexander Light, Alexander Ng, Vinson Wai‐Shun Chan, Arjun Nathan, David Cooper, Lorna Aucott, Deerush Kannan Sakthivel, Murat Akand, Pietro Piazza, Gautier Marcq, Tim O’Brien, Matthew Nielsen, Francesco Del Giudice, Kenny Simpson, Luca Orecchia, Bernardo Teixeira, Daben Dawam, Alexander Geisenhoff, G Hill, Wataru Fukuokaya, Beatriz Gutiérrez Hidalgo, Albert El-Hajj, Mostafa Elgamal, Jack B. Fanshawe, Betty Wang, Taeweon Lee, Rustom P. Manecksha, Conor McCann, Juan Gomez Rivas, Ersan Arda, Muhammed Elhadi, Sabrina Rossi, Jeremy Yuen-Chun Teoh, Paramananthan Mariappan, Veeru Kasivisvanathan, Adeyinka Laoye, Marius E. Craciun, Margaret Lyttle, Mostafa S. Shendy, ahmed abdalla, Rono Mukherjee, Aishath Mihuna, Anastasia Kantartzi, Caitlin R.M. Atkins, Juber Uddin, Faiz Motiwala, Elsie Mensah, Kimberley H.Y. Chan, Nikhil N.V. Vasdev, Gopal N. Gupta, Goran Rac, Hiten D. Patel, Mohamed M. Hassan, Anish Pushkaran, Muhammad M.S. Salik, Barnaby Barrass, Rawand Qasim Salhab, Wadee Barbarawi, Riyad Salah Aldeen, Adam Jones, Jafar Shakir, Robert H. Waterhouse, Silvian Tan, Shail Shah, Richard G. Simpson, Amar Mohee, Peter M. Smith, Seshi G. Middela, Thiru Gunendran, Yiloren Y.T. Tanidir, Nikolaos Pyrgidis, Georgios Hatzichristodoulou, Jan Mares, K.G. Keane, David Galvin, Usama Waqar, Wajahat Aziz, Muhammad Jawad Amin Malik, Syed Raziuddin Biyabani, Daniel Moser, Ekaterina Laukhtina, Shahrokh F. Shariat, Tahir Bhat, Mehmood Sa, Shikohe Masood, Esraa S. Hagag, Mohamed Ahmed Hammad, Asem Afia, Sourabh Karna, Imoh Ibiok, Giangiacomo Ollandini, Alexander E. Kiciak, Jordan A.N. Bekkema, Timothy A. Wollin, Adam Yarwood, Gokul V. Kanda Swamy, Aditya A.P Parikh, C. Sabnis, Rohan R.B. Batra, V. H. COELHO, T. Sharma, Ravindra R.S. Sabnis, Rion Healy, Sattam Ammar Faek Halaseh, Su-min Lee, Qi Yang Lim, Qing Hui Wu, Ziting Wang, Edmund Chiong, Charlotte Hughes, Omar H. Ali, Ranil Johann Boaz, Melissa Gabriel, William Finch, Omar O. Hammad, Sherif T. Heba, Jae W. Yun, Shiv Kumar Pandian, Rachel L. Oliver, Stefanos S.A. Almpanis, Fatima Adamu-Biu, Jonathan A Pushpa-Rajah, Iqbal Miakhil, Zaid Mera, Abida Sultana, John J. Potter, L. Jean Coombs, Shahzad Laghari, Israr A. Khan, Ross Warner, Oluwabukola Olaitan, James Akman, William J.F. Green, Kenny L.H. Law, Albert HG. Wong, Jie Li, Mohantha Dooldeniya, Rafał Turo, Angela Kabia, Victor E. Onowa, Arturo A. Lo Giudice, Carmen C. Scandura, Giorgio Ivan G. Russo, Adam A. Kurpik Kurpik, Krystian Kaczmarek, Artur Lemiński, Chanakya V. Anand, George G.T. Tanasescu, Lauren A. Sells, Mark Acyatan, Terence G. Smith, Utku U.L. Lokman, Meghana Ramachandra, Dominic Hodgson, Momen A.M.B Sid Ahmed, Dhanashree Moghe, Kelly K. Ong, Ali M. Tasleem, Henry H.Y. Lie, J. R. Tsu, Lucas Deán, Christopher Blick, Bogdan B.T. Toia, Sagara Ruwan Kumara R.K. Maduwe Gedara, Hadi Mohsin, John McGrath, Michael G. Ng, Brian A. Parsons, Jamie Lindsay, D. Volanis, Don S.C.R. Wijayasuriya, James D. Wilkinson, Angus White, Adam Cox, Alina Calmuc, Claire Y. Fung, Sam Taktak, Henry Lazarowicz, Benjamin Starmer, Arvinda Chippagiri, Christopher Gallegos, Eva Kerr, Nancy Penny, Euan Green, Craig M. Jones, Holly V. Colvin, Rotimi David, Melissa Davies, Leah E. Williams, Tarah Woodle, Eric Umbreit, Marilena Gubbiotti, Giacomo Maria Pirola, Matteo M. Manfredi, Michele Sica, Daniele D. Amparore, Beenish Qamar, Nada Humayun-Zakaria, Amer Hussain, Ananda Kumar Dhanasekaran, Carlo Maria Scornajenghi, Dalila Carino, Eugenio Bologna, Flavia Proietti, Martina Maggi, vincenzo asero, Vittorio Canale, Alessandro Sciarra, Costantino Leonardo, E. de Berardinis, Francesco Del Giudice, Altaf F. Mangera, Jelizaveta L.P. Pereca, Oluwaseun Akinjise-Ferdinand, Derek J. Rosario, Muhammad Ayhan Amir, Raza Zubair Khan, Umar Riaz, Muhammad Abdullah Tahir, Waqas Rahim, Jasreen Dhother, Guleed Mohamed, Yen Nee Jenny Bo, Yew Fung Y.F. Chin Chin, Raghav K. Varma, Andrew Elves, Ioannis Manolitsis, Lazaros I. Tzelves, Andreas Skolarikos, Kara N. Babaian, Lia B. Case, Tiffany Damm, Danuta Dynda, Ahmad J.N.V. Elmansouri, Faisal F.E. Edris, James Voss, Charlotte Parfitt, George R.E. Buckland, Vaki Antoniou, Mriganka M. Sinha, James Douglas, Juliet Campbell, Jasper Bondad, sangawaka Khuoge, Chrissie Gipson, Arabella Lecoyte, Laura Waley, R Hawthorne, Alexander Ridgwayy, Kate S. Warren, Sarveen Maniarasu, Rahul Mistry, Hassan Shembesh, Claudio Simeone, Francesca Mondini, Stefania Zamboni, Nazareno Roberto Suardi, Luke Stroman, Mahabub Hassan, Benjamin Ayres, Rory T.M. Pinkney, Omar El‐Taji, John McCabe, S. Considine, Paul Ryan, Sydney Sparanese, Brian E. Mayson, AbisolaE Oliyide, Ijeoma N.C. Chibuzo, Sophie Vaggers, James Dyer, N. O’Sullivan, Zakya Penny, Rowan Z. Casey, Daniel Z.P. Yong, Jeffrey Leow, Zhen Wei Choo, Zhenbang Liu, Yew Lam Chong, Sujoy Gupta, Gaurav Aggarwal, Alex Qinyang Liu, David Leung, Jeremy YuenChun Teoh, Ning Xu, Yun Zhi Lin, Yong Wei yong Wei, E Nishi, Hirotaka Suzuki, Jun Miki, Maria Okamoto, Takafumi Yanagisawa, Yu Imai, Akihiro Matsukawa, Koki Obayashi, Shoji Kimura, W. Fukuokaya, Kenneth R. MacKenzie, Alexandra Miller, Campbell D. Tait, Hannah Thorman, Simona Ippoliti, Petre Cristian Ilie, Ashish M. Kamat, Eleanor F. Zimmermann, Omikunle Babawale, Victoria Mitchell, Seanan O’Rourke, Goktan G. Oz, Mehmet G.G. Arikan, I H Atakan, Ersan E. Arda, Abdalkdos Dikna, Reem Ghmagh, Benjamin H. Rosenfeld, Benjamin T. Ristau, Amy Ross, Rachel O’Halloran, John Hayes, Samuel B. Gray, Sophie M. Verlinden, Aniek Maessen, Peter-Paul M. Willemse, A. Travino, Andrea Iannuzzi, Francesco Tedesco, N. Deanesi, Roberto Mario M. Scarpa, Rocco R. Papalia, Elizabeth K. Day, Hafsa Shirwac, Raian Jaibaji, Stanley Tang, Clio Kennedy, Bernadett Szabados, Cinzia Baldini, J. Nowers, Piyush P.B. Sarmah, Kevin G. Williams, Lieo Jiun Tan, A. Boden, Samuel J. Simpkins, Rehan S.S. Khan, Manoj Ravindraanandan, Artemisia Lango, M S Kitchen, L Gommersall, MEGAN Y. THOMAS, Abdullah Al-Mitwalli, J. Featherstone, Lucia Pitoni, Maria Vittoria De Angelis, Rocco Fracesco R.F.D. Delle Fave, Erika Palagonia, Lucio Dell’Atti, Andrea Benedetto A.B. Galosi, L. Baekelandt, B Van Cleynenbreugel, Steven Joniau, Chu Ann Chai, Lim L.Z.K. Jeffery ZK, W C Yeoh, Kanesh Kumaran Seevalingam, Teng Aik T.A. Ong, Andrew M. Fang, Sol C. Moon, Glaser Zr, Soroush Rais-Bahrami, Bettyy H. Wang, Niels B. Jacobsen, Behzad Abbasi, Jason L. Lui, Kevin D.D Li, Benjamin N. Breyer, Rodrigo Pessoa, Simon Kim, Rylee R.J.F. Funkhouser, Jonathan K. Zakrajsek, Janet E.B. Kukreja, M. Şahin Sevim, Ozgur O. Kazan, Bekir Aras, Matthew M. Banti, Eugene E.K.L. Lee, Brandon K.G. Kannady, Jonathan Mayo Maldonado, Patrick J. Hensley, Madeleine McSpadden, Danielle Ray, Jennifer L. Randolph, Katie S. Murray, James Catto, Atanas S. Ivanov, Petar Antonov, Mohamed Edwan, A. Elkarta, M. Elbaset, O. Ezzat, Rawdy Ashour, Ahmed Mosbah, Peter C. Black, Natasha Chari, Panagiotis Nikolinakos, David Sj Ellis, Dimitrios I. Papadopoulos, Konstantinos Charitopoulos, Michelle Carey, E. M. Gordon, Dmitri Korotõts, Rauno Okas, David Hua Wu H. Lau, Osman El-Koubani, Jennifer R.S. Ayers, Saddaf Hina, Tobias Gartner, Joe E.G. James, Keith R.S. Simpson, Mohamed E. Ibrahim, Mohammed Dallash, Samer Jallad, Zuzana Bencatova, Rustam Karanjia, Danielle Whiting, R. Frymann, Soma S.F. Farag, Jessica A.S. Whitburn, Saiful Miah, Hany Mohamed Khattab, Filip Kondylis

Bibliographic record

VenueEuropean Urology · 2025

Typearticle

Languageen

FieldMedicine

TopicBladder and Urothelial Cancer Treatments

Canadian institutionsUniversity of British ColumbiaUniversity of Alberta

FundersKARL STORZMedacUrology FoundationPhotocureRosetrees Trust

KeywordsAuditRandomized controlled trialBladder cancerIntervention (counseling)DocumentationAdjuvant chemotherapyAdjuvantClinical trial

DOI10.1016/j.eururo.2025.09.4174

Abstract

fetched live from OpenAlex

BACKGROUND AND OBJECTIVE: We aimed to determine whether audit, feedback, and education improves surgical performance after transurethral resection of bladder tumour surgery for non-muscle-invasive bladder cancer and as a secondary aim if it reduced recurrence rates. METHODS: This cluster randomised controlled trial compared audit and feedback plus peer comparison and education, with audit alone for four coprimary outcomes: (1) Single-instillation chemotherapy, (2) detrusor muscle sampling, (3) documentation of tumour features, and (4) resection completeness. Early recurrence was a secondary outcome. KEY FINDINGS AND LIMITATIONS: A total of 100 sites were randomised to intervention and 101 to control. In total, 14 915 patients were included. Intervention sites significantly improved documentation of tumour features (adjusted mean difference [95% confidence interval {CI}]: 6.0 [1.8, 10], p = 0.005) and of resection completeness (adjusted mean difference [95% CI]: 5.5 [1.5, 9.5], p = 0.007). There was no statistically significant difference in chemotherapy use (adjusted mean difference [95% CI]: 0.3 [-4.7, 5.3], p = 0.9) or detrusor muscle sampling (adjusted mean difference [95% CI]: 2.6 [-1.3, 6.4], p = 0.2). There was no statistically significant difference in early recurrence rate between arms (adjusted odds ratio [95% CI]: 1.02 [0.8, 1.4], p = 0.9); however, in the control arm, the early recurrence rate reduced compared with baseline (adjusted odds ratio [95% CI]: 0.7 [0.6, 0.9]). CONCLUSIONS AND CLINICAL IMPLICATIONS: Audit and feedback with education improved the documentation of important surgical findings that influence clinical management, but not the performance of detrusor muscle sampling, adjuvant chemotherapy use, or early recurrence rates. Improvements observed in the control arm may explain a lack of effect of the intervention in some outcomes.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001

metaresearch head score (Gemma)0.001

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesnone

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.109

Threshold uncertainty score0.574

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.001	0.001
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.001	0.000
Bibliometrics	0.000	0.000
Science and technology studies	0.000	0.000
Scholarly communication	0.000	0.000
Open science	0.000	0.000
Research integrity	0.000	0.000
Insufficient payload (model declined to judge)	0.000	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016

GPT teacher head0.280

Teacher spread0.265 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.

Study designRandomized trial

Domainnot available

GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3

Published2025

Admission routes1

Has abstractyes

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