Protect AD: Realizing New Clinical Trial Possibilities
Bibliographic record
Abstract
BACKGROUND: The aim of PROTECT-UK was to deliver an online ageing cohort for UK adults to facilitate large-scale high quality longitudinal data collection and delivery of remote and hybrid clinical trials as an innovative cost-effective low-risk research solution. METHOD: PROTECT-UK recruits adults over 40 in the UK through a website and app. All activities are completed online including annual neuropsychological assessment with the computerized FLAME battery, neuropsychiatric symptoms, physical and mental health and lifestyle data. DNA is collected remotely. Clinical trials are delivered within the study platform via full consent-for-contact and cohort pre-screening which facilitates rapid recruitment. Participant engagement and retention is facilitated through access to evidence-based cognitive training, regular communications and the opportunity to inform the research agenda. RESULT: PROTECT-UK has collated data from 54,000 participants to date and has 30,000 active participants. International instances of PROTECT are live in Norway (n = 5000) and Canada (n = 2500). Participant retention in the UK is up to 80% year-on-year. 17,000 DNA samples have been collected. PROTECT has recruited over 60,000 participants to online clinical trials, including large-scale trials of cognitive training that demonstrated significant benefits and nutritional supplement trails including vitamin D supplementation in people with early cognitive deficits (n = 654), dietary nitrate in people with the ApoE4 gene (n = 120) and a hybrid trial of a Mediterranean Diet supplement involving a sub-group recalled for venepuncture and physiological assessment (n = 150). Trials have achieved up to 95% retention and data completeness, with treatment compliance comparable to in-person trials. Genomic data has contributed to several published and ongoing studies including demonstrating increased schizophrenia and Alzheimer polygenic risk in people with mild behavioural impairment. Characterisation of the cohort shows there are >400 participants with GBA mutations and >800 E4 homozygotes with consent for contact. CONCLUSION: With proactive approaches, long term engagement can be achieved in digital platform studies. PROTECT has shown the feasibility of remotely running efficient and high quality clinical trials and collecting genomic and other biological materials to enhance research outputs.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".