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Record W7117303107 · doi:10.1002/alz70858_105729

Understanding physical activity interventions for people living with dementia: A systematic review and meta‐analysis

2025· article· en· W7117303107 on OpenAlexaff
Laura E. Middleton, Liu Grace, Vanessa Vucea‐Tirabassi, Christine Aiken, Jennifer Bethell, Heather A. Cooke, Heather Keller, Teresa Liu‐Ambrose, Myrna Norman, Megan E O'Connell, Jackie Stapleton, Ingrid Waldron, Sarah Wu, Marie‐Lee Yous, Carrie McAiney

Bibliographic record

VenueAlzheimer s & Dementia · 2025
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsMcMaster UniversityUniversity of British ColumbiaVancouver Coastal Health Research InstituteVancouver Coastal HealthUniversity of SaskatchewanAlzheimer Society of CanadaResearch Institute for AgingUniversity of WaterlooToronto Rehabilitation InstituteUniversity of Toronto
Fundersnot available
KeywordsPsychological interventionPhysical activityIntervention (counseling)Activities of daily livingSystematic review

Abstract

fetched live from OpenAlex

BACKGROUND: There is limited research focused on lifestyle interventions among people living with dementia with recent systematic reviews primarily focused on the impact of exercise on cognition. However, functional abilities and quality of life (QoL) are the outcomes most consistently prioritized by people living with dementia, care partners, and healthcare professionals. We conducted a systematic review to understand the impact of two lifestyle interventions (physical activity, nutrition) on the functional abilities, QoL, and nutritional status (nutrition interventions only) of people with dementia living in the community. The findings here focus on the effects of physical activity interventions. METHOD: Systematic literature searches for peer-reviewed intervention studies were conducted in four databases (MEDLINE, EMBASE, Scopus, CINAHL). Articles were exported to Covidence, where duplicates were removed and two independent reviewers performed study selection, data extraction, and risk of bias assessments. A narrative synthesis was conducted. A meta-analysis is currently ongoing. RESULT: Fifty-five studies met the inclusion criteria and were included in this review. Data extraction revealed diverse study designs, characteristics and types of physical activity interventions, and measures for functional abilities and QoL. Nine studies measured the QoL of people living with dementia using the self-reported Quality of Life Alzheimer's Disease (QoLAD) tool. Four of these studies showed a significant improvement in the QoLAD. Twenty-five studies reported using the Timed Up and Go Test (TUG) to measure mobility. Fifteen of these studies demonstrated an improvement in the TUG, with nine of the studies revealing significant improvements. Six studies measured functional capacity using the 6-minute walk test. Two of these studies showed a significant improvement in the 6-minute walk test. CONCLUSION: The results from this review highlight the impact of physical activity interventions on QoL and mobility for people living with dementia. The meta-analysis will provide quantitative estimates for the effects of physical activity interventions on specific outcomes related to functional abilities and QoL. Furthermore, exploring the effectiveness by intervention dose and delivery in subgroup analyses will also allow us to better inform guidelines regarding interventions, programs, and policy related to physical activity interventions. Lastly, we will identify knowledge gaps where research is needed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.024
metaresearch head score (Gemma)0.056
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (broad)
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.978
Threshold uncertainty score0.128

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0240.056
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0220.033
Bibliometrics0.0090.008
Science and technology studies0.0010.001
Scholarly communication0.0040.003
Open science0.0030.002
Research integrity0.0030.002
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.121
GPT teacher head0.385
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designMeta-analysis
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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