Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS
Bibliographic record
Abstract
Lower-risk (LR) myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by ineffective hematopoiesis, abnormal blood cell development, and a relatively low risk of progression to acute myeloid leukemia or death [ 1 ]. Anemia is a hallmark of LR-MDS and often leads to chronic red blood cell (RBC) transfusion dependence (TD), which is a reflection of further bone marrow failure, increased disease burden, and shortened survival ( ~ 3–9 years) [ 1 , 2 ]. These patients present with a clinical challenge, in that the primary therapeutic goal is to improve the cytopenias and manage their symptoms (typically through supportive care and targeted pharmacotherapeutics) rather than controlling the malignant hematopoiesis [ 3 , 4 , 5 ]. There is an unmet need for improvements in therapies for LR-MDS that can target the underlying cause of the disease.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".