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Record W7163170164 · doi:10.48448/0136-xg27

Harmonization on Non-targeted Testing in Mass Spectrometry

2025· other· W7163170164 on OpenAlexaff
AOAC 2025, Thomas Gude

Bibliographic record

VenueUnderline Science Inc. · 2025
Typeother
Language
Field
Topic
Canadian institutionsSt. Thomas Hospital
Fundersnot available
KeywordsWorkflowHarmonizationSet (abstract data type)Presentation (obstetrics)Focus (optics)Test (biology)Working groupFocus group

Abstract

fetched live from OpenAlex

Non-targeted methods have been gaining ground in recent decades, especially with the tremendous development of high-resolution mass spectrometry. The challenges for non-targeted methods are becoming increasingly necessary as there are limited guidelines to regulate and harmonize the methods worldwide. AOAC-Europe and have been signed a Memorandum of understanding for this sector. Two years ago, a series of Webinars on "Trends & Challenges for Non-Targeted Methods" have been started. As a result of this webinars a joint working group was set up with the aim of providing guidelines for the harmonization of non-targeted methods, mainly based on Mass Spectrometry. So far, the starting working group was now split into five subgroups dealing with food, authenticity, environmental/water, packaging and metabolomic testing. As an initial step the five groups are summarizing definitions and workflows for non-target testing. Based on the theses results a harmonized wording and where possible a harmonized workflow incl. validation should be created. The aim of this presentation is to present especially the result of the packing (food contact material area). The current status of initiation of common parameters as well harmonized criteria for reporting Screening (NIAS) results is presented. The focus of this harmonisation activity is on descriptive physico-chemical parameter, which allow the reader of such Screening reports to find out easily, if it worthwhile to compare results or are the test results achieved based on different assumptions. Currently the focus is only on the results but not on comparability, which lead to massive problems in understanding.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.010
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Bibliometrics, Science and technology studies, Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow), Bibliometrics, Insufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.865
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.010
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0160.047
Science and technology studies0.0010.003
Scholarly communication0.0010.001
Open science0.0040.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0050.013

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.026
GPT teacher head0.292
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designSimulation or modeling
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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