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4,299,418 works, Canadian by any of four routes.

Every filter state is a URL; the URL is the query; the query is citable via /q/⟨hash⟩. The page, the API and the export parse the same parameters.

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The current cohort, streamed from the database: every work column, the machine labels, the provisional scores, and the per-row validation status. Exports are capped at 100,000 rows. Mints a permanent /q/ link for this exact query. The same filters always produce the same link, whoever asks.

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Phosphodiesterase function and regulation
Retraction
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Direct Codex and Gemma labels are unvalidated and sparse. Distilled predictions cover the full frame and are also unvalidated. Choose the evidence source explicitly; absence of a direct label is never a negative label.

affaffiliation
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The four routes compose: require the funder route and exclude affiliation to get the funder-only stratum no affiliation-based frame ever sees.

428 results · 1 filter active ·
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20002025
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Machine labels · sparse coverage
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An unlabeled work is unknown, not a negative. Label coverage is reported on every query.
428 works in the cohort · of 4,299,418page 5 of 9

Labels cover 0 of 428 works in this cohort. The rest are unlabeled, which is not a negative label: the label table is sparse today and grows as labeling rounds land.

Distilled predictions cover 428 of 428 works in this cohort. Predictions are machine_predicted_unvalidated teacher distillation outputs. Candidate is the union; consensus is the intersection.

afffundunlabeled
cAMP-dependent allostery and dynamics in Epac: an NMR view
Rajeevan Selvaratnam, Madoka Akimoto, Bryan VanSchouwen, Giuseppe Melacini
2012· review· en· Biochemical Society Transactions· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · metaepi_narrowconsensus · none
22
citations
affno abstractunlabeled
Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[11C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues
Miran Kenk, Michael Greene, Mireille Lortie, Robert A. deKemp, Rob Beanlands, Jean N. DaSilva
2008· article· en· Nuclear Medicine and Biology· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · noneconsensus · none
20
citations
affno abstractunlabeled
GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells
Taruna Joshi, Omar Hamed, Stacey Tannheimer, Gary B. Phillips, Clifford D. Wright, Musong Kim +3 more
2016· article· en· Journal of Pharmacology and Experimental Therapeutics· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · noneconsensus · none
19
citations
fundno affunlabeled
The in vivo efficacy and side effect pharmacology of <scp>GS</scp>‐5759, a novel bifunctional phosphodiesterase 4 inhibitor and long‐acting <i>β</i><sub>2</sub>‐adrenoceptor agonist in preclinical animal species
M Salmon, Stacey Tannheimer, Terry T. Gentzler, Zhuoya Cui, Eric A. Sorensen, Kimberly C. Hartsough +11 more
2014· article· en· Pharmacology Research & Perspectives· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · noneconsensus · none
19
citations
affno abstractunlabeled
Peripheral Phosphodiesterase 4 Inhibition Produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) Prevents Experimental Autoimmune Encephalomyelitis
Craig S. Moore, N. Earl, Richard Frenette, Angela Styhler, Joseph A. Mancini, Donald W. Nicholson +3 more
2006· article· en· Journal of Pharmacology and Experimental Therapeutics· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · metaepi_narrowconsensus · none
17
citations
affno abstractunlabeled
OP0169 Apremilast, an Oral Phosphodiesterase 4 Inhibitor, is Associated with Long-Term (104-Week) Improvements in Enthesitis and Dactylitis in Patients with Psoriatic Arthritis: Pooled Results from Three Phase 3, Randomized, Controlled Trials
Dafna D. Gladman, Arthur Kavanaugh, Ade Adebajo, Juan J. Gómez‐Reino, J. Wollenhaupt, Maurizio Cutolo +7 more
2015· article· en· Annals of the Rheumatic Diseases· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · noneconsensus · none
16
citations
afffundunlabeled
DISC1 and Striatal Volume: A Potential Risk Phenotype For mental Illness
M. Mallar Chakravarty, Daniel Felsky, Maria Tampakeras, Jason P. Lerch, Benoit H. Mulsant, James L. Kennedy +1 more
2012· article· en· Frontiers in Psychiatry· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · noneconsensus · none
16
citations
affunlabeled
Apremilast and its role in psoriatic arthritis
Vijay K. Sandhu, Lihi Eder, Jensen Yeung
2020· review· it· Giornale Italiano di Dermatologia e Venereologia· Biochemistry, Genetics and Molecular Biology
distilled prediction:candidate · metaepi_narrow+research_integrityconsensus · none
14
citations
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