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Record W1605691217 · doi:10.1038/nrg1351

Integrating ethics and science in the International HapMap Project

2004· review· en· W1605691217 on OpenAlexfundno aff
Morris W. Foster

Bibliographic record

VenueNature Reviews Genetics · 2004
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicRace, Genetics, and Society
Canadian institutionsnot available
FundersNational Institute of Biomedical Imaging and BioengineeringNational Institute of Dental and Craniofacial ResearchNational Institute of Environmental Health SciencesNational Institute of Neurological Disorders and StrokeNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseasesNational Institute of General Medical SciencesW. M. Keck FoundationNational Institute on Deafness and Other Communication DisordersNational Institute on Drug AbuseNational Institute of Mental HealthNational Cancer InstituteNational Eye InstituteGénome QuébecNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthMinistry of Education, Culture, Sports, Science and TechnologyMinistry of Science and Technology of the People's Republic of ChinaNational Natural Science Foundation of ChinaBeijing Normal UniversityChinese Academy of SciencesUniversity Grants CommitteeNational Institute on AgingMinistry of Education, Science and TechnologyInnovation and Technology CommissionNational Human Genome Research InstituteWellcome TrustGenome Canada
KeywordsInternational HapMap ProjectGenomicsVariation (astronomy)BiologyResearch ethicsResource (disambiguation)PopulationEngineering ethicsSociologyGeneticsHuman genomeBiotechnologyGenomeComputer science

Abstract

fetched live from OpenAlex

Genomics resources that use samples from identified populations raise scientific, social and ethical issues that are, in many ways, inextricably linked. Scientific decisions about which populations to sample to produce the HapMap, an international genetic variation resource, have raised questions about the relationships between the social identities used to recruit participants and the biological findings of studies that will use the HapMap. The sometimes problematic implications of those complex relationships have led to questions about how to conduct genetic variation research that uses identified populations in an ethical way, including how to involve members of a population in evaluating the risks and benefits posed for everyone who shares that identity. The ways in which these issues are linked is increasingly drawing the scientific and ethical spheres of genomics research closer together.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.007
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.993
Threshold uncertainty score0.038

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0070.007
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0040.005
Science and technology studies0.0010.008
Scholarly communication0.0040.008
Open science0.0020.003
Research integrity0.0070.008
Insufficient payload (model declined to judge)0.0030.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.058
GPT teacher head0.416
Teacher spread0.358 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainMethods
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations330
Published2004
Admission routes1
Has abstractyes

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