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Record W2120841701 · doi:10.1371/journal.pbio.0060073

Research Ethics Recommendations for Whole-Genome Research: Consensus Statement

2008· article· en· W2120841701 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenuePLoS Biology · 2008
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsMemorial University of NewfoundlandOntario GenomicsCanadian Institutes of Health ResearchUniversity of British ColumbiaUniversity of TorontoUniversité de MontréalUniversity of Alberta
FundersInstitute of GeneticsOntario GenomicsCanadian Institutes of Health ResearchOntario Genomics InstituteNational Institutes of HealthGenome Alberta
KeywordsBiologyStatement (logic)Research ethicsGenomeEngineering ethicsComputational biologyMEDLINEGeneticsBiotechnologyGenePolitical scienceLaw

Abstract

fetched live from OpenAlex

Interest in whole-genome research has grown substantially over the past few months. This article explores the challenging ethics issues associated with this work.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmaResearch integrity
Domain: not available · Genre: Other
About the Canadian research system: no · About a Canadian topic: no
Not applicablelow
gptMetaresearch
Domain: Methods · Genre: Commentary
About the Canadian research system: no · About a Canadian topic: no
Not applicablemedium
models splitAgreement compares identical category sets and study designs across arms.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.038
metaresearch head score (Gemma)0.114
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Science and technology studies, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.751
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0380.114
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.004
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0010.010
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.959
GPT teacher head0.726
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it